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Aggregated β-amyloid interacts with fibrinogen

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9936686

PubChem

R-HSA-9936686

Description

Fibrinogen and fibrin, proteins typically confined to the bloodstream, can accumulate in the brain's extravascular space due to blood-brain barrier disruptions associated with various neurological conditions. In the brain, fibrinogen or fibrin can co-aggregate with amyloid beta (Aβ) peptides (APP(672-711), APP(672-713)) - a hallmark of Alzheimer's disease - potentially leading to the formation of abnormal blood clots that are more resistant to fibrinolysis. This process may contribute to the vascular pathology observed in Alzheimer's disease patients.

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Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 4** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P02671	Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]	FGA	view
P02675	Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]	FGB HEL-S-78p	view
P02679	Fibrinogen gamma chain	FGG PRO2061	view
P05067	Amyloid-beta precursor protein	A4 AD1 APP	view

Displaying **all 3** entries
GlyCosmos Lectin	UniProt ID	Lectin Name	Pathway Viewer
GL_005388	P02671	Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]	view
GL_005389	P02675	Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]	view
GL_005390	P02679	Fibrinogen gamma chain	view

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