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MIRAGE
Interleukin-6

Summary
UniProt ID
P05231
Gene Symbol
  • IFNB2
  • IL6
Gene ID
3569
Organism
Homo sapiens (human)
GlyGen
P05231
PubChem
P05231
The Human Metabolome Database
HMDBP02087
Re-Glyco
P05231
Annotation
Keyword
  • 3D-structure
  • Acute phase
  • Cytokine
  • Direct protein sequencing
  • Disulfide bond
  • Glycoprotein
  • Growth factor
  • Phosphoprotein
  • Reference proteome
  • Secreted
  • Signal
Gene Ontology (GO)
Displaying all 4 entries
GO Term
extracellular region
extracellular space
endoplasmic reticulum lumen
interleukin-6 receptor complex
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 2 entries
Position Description PubMed ID GlyTouCan ID Source
73 N-linked (GlcNAc...) asparagine
89
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying entries 1 - 10 of 11 in total
Pathway Name Organism
ADORA2B mediated anti-inflammatory cytokines production Homo sapiens
CD163 mediating an anti-inflammatory response Homo sapiens
Interleukin-10 signaling Homo sapiens
Interleukin-4 and Interleukin-13 signaling Homo sapiens
Interleukin-6 signaling Homo sapiens
MAPK1 (ERK2) activation Homo sapiens
MAPK3 (ERK1) activation Homo sapiens
Post-translational protein phosphorylation Homo sapiens
Regulation of IGF Activity by IGFBP Homo sapiens
Senescence-Associated Secretory Phenotype (SASP) Homo sapiens
Disease
Displaying entries 1 - 10 of 44 in total
DO ID Disease Name Source
DOID:0060688 arteriovenous malformations of the brain
DOID:0060901 lymphoplasmacytic lymphoma
DOID:0080208 metabolic dysfunction-associated steatotic liver disease
DOID:0080547 metabolic dysfunction-associated steatohepatitis
DOID:10140 dry eye syndrome
DOID:10534 stomach cancer
DOID:10608 celiac disease
DOID:10754 otitis media
DOID:10763 hypertension
DOID:10941 intracranial aneurysm
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025