GlyCosmos Portal

Submissions

Heparin cofactor 2

Summary

UniProt ID: P05546
Gene Symbol: SERPIND1 HCF2
Gene ID: 3053
Organism: Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011395

GlyConnect

Heparin cofactor 2

GlyGen

P05546

PubChem

P05546

The Human Metabolome Database

HMDBP01712

The O-GlcNAc Database

P05546

RaftProt

P05546

Re-Glyco

P05546

Annotation

Keyword: 3D-structure Alternative splicing Chemotaxis Direct protein sequencing Disease variant Glycoprotein Heparin-binding Phosphoprotein Proteomics identification Reference proteome Repeat Serine protease inhibitor Signal Sulfation Thrombophilia

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	Reference
chemotaxis
blood coagulation	IEA	GO_REF

GO Hierarchy

biological process

multicellular organismal process [inference]

coagulation [inference]

blood coagulation

locomotion [inference]

taxis [inference]

chemotaxis

biological regulation [inference]

regulation of biological quality [inference]

regulation of body fluid levels [inference]

hemostasis [inference]

blood coagulation

Displaying entries **1 - 5** of 6 in total

1

2

Next ›

Last »
GO Term	Evidence Code	Reference
extracellular region	NAS	PMID
extracellular region	TAS	Reactome
extracellular region	HDA	PMID
obsolete extracellular space
endoplasmic reticulum lumen	TAS	Reactome

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 4** entries
GO Term	Evidence Code	Reference
endopeptidase inhibitor activity	TAS	PMID
serine-type endopeptidase inhibitor activity	IBA	GO_REF
serine-type endopeptidase inhibitor activity	IEA	GO_REF
heparin binding

GO Hierarchy

molecular function

binding [inference]

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MKHSLNALLIFLIITSAWGGSKGPLDQLEKGGETAQSADPQWEQLNNKNLSMPLLPADFHKENTVTNDWIPEGEEDDDYLDLEKIFSEDDDYIDIVDSLSVSPTDSDVSAGNILQLFHGKSRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSCLLFMGRVANPSRS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 14 in total

1

2

Next ›

Last »
Position	Description	PubMed ID	GlyTouCan ID	Source
31		28035807	G57321FI	GlyGen
37		30459171	G43417UB	GlyGen
49	N-linked (GlcNAc...) (complex) asparagine	16335952 19139490 19159218 24279413 29391424 29671580 29741879 32125861 37074911	G76868JS G56518TU G13694XX G15169WU G70232NH G94917XT G70888PK G06247RL G47518TP G37881RL G80075MS G11629QQ G57776ZS G86880BF G27947YN G52527GH G04854VP G94470IW G98611JV G40834TG G43669FQ G22310AV G45395BF G88374WZ G59324HL G02030ZB G43223CG G26330YA G10846ZT G40574BA G08918WF G47737VJ G75983OB G00875VP G00912UN G42358LZ G48414YA G27058EU G70619PT G06356OH G59626AS G47644PP G10486CT G95865ZB G11314AS G22572EH G41247ZX G57776ZU G57317CE G28681TP	GlycoProtDB UniProt GlyGen GlyConnect
51		30459171	G43417UB G29068FM	GlyGen
100		30459171	G43417UB	GlyGen
102		30459171	G53434XO G43417UB	GlyGen
104		30459171	G43417UB G29068FM	GlyGen
188	N-linked (GlcNAc...) asparagine	12169660 16335952 19159218 24279413 29391424 29671580 29741879 37074911	G70232NH G70888PK G06247RL G47518TP G37881RL G27947YN G90093AU G24954UD G04854VP G94470IW G40834TG G43669FQ G45395BF G02030ZB G31986NC G26330YA G10846ZT G40574BA G82830MN G05933EN G08918WF G00875VP G00912UN G48414YA G78790NZ G27915IV G83646BJ G27058EU G72747WU G70619PT G06356OH G59626AS G45504EY G62765YT G10486CT G95865ZB G22572EH G57776ZU G57317CE G28681TP	GlycoProtDB UniProt GlyGen GlyConnect
285		31492838 38253038 38665916	G49108TO	The O-GlcNAc Database
328		31492838 38253038 38665916	G49108TO	The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
Amplification and propagation of coagulation cascade	Homo sapiens
Fibrin formation	Homo sapiens
Post-translational protein phosphorylation	Homo sapiens
Regulation of IGF Activity by IGFBP	Homo sapiens
Regulation of clotting cascade	Homo sapiens

Disease

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0111901	heparin cofactor II deficiency	Alliance of Genome Resources
DOID:0050117	disease by infectious agent	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements