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Fibrin formation

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9769733

PubChem

R-HSA-9769733

Description

This Reactome module describes the multi-step process of fibrin formation, which is initiated by the thrombin (FIIa)-catalyzed conversion of fibrinogen molecules to fibrin monomers (Ni F et al., 1989; Pechik I et al., 2006; Riedel T et al., 2011). Fibrin monomers rapidly and spontaneously associate into large multimers, which in turn elongate into protofibrils that later aggregate to form fibers, creating a three-dimensional network. This structural organization is essential for the mechanical properties of the clot (reviewed by Doolittle 1984; Litvinov RI & Weisel JW 2017; Feller T et al., 2022). The fibrin network is further stabilized by Ca2+ -dependent cross-linking of fibers, which is mediated by the thrombin-activated factor XIII (FXIIIa). Adhesion of integrin αIIbβ3, a platelet surface receptor, to the fibrin network contributes to platelet aggregation and stabilizes the forming clot (Litvinov RI et al., 2016; Höök P et al., 2017). The process of fibrin clot formation has been reviewed in detail (Medved L & Weisel JW 2009; Weisel JW & Litvinov RI 2017; Pieters M& Wolberg AS 2019; Butera D & Hogg PJ 2020; Murano G 2024).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 13 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P00488	Coagulation factor XIII A chain	F13A F13A1	view
P00734	Prothrombin	F2	view
P01008	Antithrombin-III	AT3 PRO0309 SERPINC1	view
P02671	Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]	FGA	view
P02675	Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]	FGB HEL-S-78p	view
P02679	Fibrinogen gamma chain	FGG PRO2061	view
P04070	Vitamin K-dependent protein C	PROC	view
P05106	Integrin beta-3	GP3A ITGB3	view
P05154	Plasma serine protease inhibitor	PCI PLANH3 PROCI SERPINA5	view
P05160	Coagulation factor XIII B chain	F13B	view

Displaying **all 3** entries
GlyCosmos Lectin	UniProt ID	Lectin Name	Pathway Viewer
GL_005388	P02671	Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]	view
GL_005389	P02675	Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]	view
GL_005390	P02679	Fibrinogen gamma chain	view

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