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MIRAGE
Vitamin K-dependent protein C

Summary
UniProt ID
P04070
Gene Symbol
  • PROC
Gene ID
5624
Organism
Homo sapiens (human)
GlycoProtDB
GPDB0011352
GlyConnect
GlyGen
P04070
PubChem
P04070
The Human Metabolome Database
HMDBP02002
Re-Glyco
P04070
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Calcium
  • Cleavage on pair of basic residues
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • EGF-like domain
  • Endoplasmic reticulum
  • Gamma-carboxyglutamic acid
  • Glycoprotein
  • Golgi apparatus
  • Hydroxylation
  • Phosphoprotein
  • Reference proteome
  • Repeat
  • Secreted
  • Serine protease
  • Signal
  • Thrombophilia
  • Zymogen
Gene Ontology (GO)
Displaying all 6 entries
GO Term
extracellular region
extracellular space
endoplasmic reticulum
endoplasmic reticulum lumen
Golgi apparatus
Golgi lumen
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying all 2 entries
GO Term
serine-type endopeptidase activity
calcium ion binding
Annotation information from UniProt.
Sequence
MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECIEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSCDCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVKFPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 7 entries
Position Description PubMed ID GlyTouCan ID Source
19 O-linked (GalNAc...) threonine
139
290 N-linked (GlcNAc...) asparagine
355 N-linked (GlcNAc...) asparagine
371 N-linked (GlcNAc...) asparagine; atypical; partial
382
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 8 entries
Pathway Name Organism
Cell surface interactions at the vascular wall Homo sapiens
Common Pathway of Fibrin Clot Formation Homo sapiens
Gamma-carboxylation of protein precursors Homo sapiens
Intrinsic Pathway of Fibrin Clot Formation Homo sapiens
Post-translational protein phosphorylation Homo sapiens
Regulation of IGF Activity by IGFBP Homo sapiens
Removal of aminoterminal propeptides from gamma-carboxylated proteins Homo sapiens
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Homo sapiens
Disease
Displaying entries 1 - 10 of 13 in total
DO ID Disease Name Source
DOID:0060903 thrombosis
DOID:0111902 thrombophilia due to activated protein C resistance
DOID:0111904 autosomal recessive thrombophilia due to protein C deficiency
DOID:0111909 autosomal dominant thrombophilia due to protein C deficiency
DOID:10591 pre-eclampsia
DOID:14115 toxic shock syndrome
DOID:2450 central retinal vein occlusion
DOID:2452 thrombophilia
DOID:2841 asthma
DOID:2988 antiphospholipid syndrome
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025