GlyCosmos Portal

Submissions

Removal of aminoterminal propeptides from gamma-carboxylated proteins

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-159782

PubChem

R-HSA-159782

Description

Furin is an endopeptidase localized to the Golgi membrane that cleaves many proteins on the carboxyterminal side of the sequence motif Arg-[any residue]-(Lys or Arg)-Arg (Jones et al. 1995; Leduc et al. 1992). In the case of gamma-carboxylated proteins, if this cleavage does not occur, the proteins are still secreted but do not function properly (Bristol et al. 1993; Lind et al. 1997; Wasley et al. 1993). The aminoterminal fragments, "propeptides", generated in this reaction have no known function; the carboxylated, cleaved proteins are delivered to the cell membrane or secreted from the cell.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 9** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P00734	Prothrombin	F2	view
P00740	Coagulation factor IX	F9	view
P00742	Coagulation factor X	F10	view
P04070	Vitamin K-dependent protein C	PROC	view
P07225	Vitamin K-dependent protein S	PROS PROS1	view
P08709	Coagulation factor VII	F7	view
P09958	Furin	FUR FURIN PACE PCSK3	view
P22891	Vitamin K-dependent protein Z	PROZ	view
Q14393	Growth arrest-specific protein 6	AXLLG GAS6	view

If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".

About Release Notes Help Feedback

Click here to visit the beta site.