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Coagulation factor X

Summary
UniProt ID
P00742
Gene Symbol
  • F10
Organism
Homo sapiens (human)
External Links
GlyConnect
GlyGen
P00742
PubChem
P00742
The Human Metabolome Database
HMDBP02011
The O-GlcNAc Database
P00742
Annotation
Keyword
  • 3D-structure
  • Blood coagulation
  • Calcium
  • Cleavage on pair of basic residues
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • EGF-like domain
  • Gamma-carboxyglutamic acid
  • Glycoprotein
  • Hydroxylation
  • Reference proteome
  • Repeat
  • Secreted
  • Serine protease
  • Signal
  • Zymogen
Gene Ontology (GO)
Annotation information from UniProt.
Sequence
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying entries 1 - 10 of 14 in total
Position Description PubMed ID GlyTouCan ID Source
188
189
190
197
199 O-linked (GalNAc...) threonine
203
211 O-linked (GalNAc...) threonine
221 N-linked (GlcNAc...) asparagine
231 N-linked (GlcNAc...) asparagine
476
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 9 entries
Pathway Name Organism
Common Pathway of Fibrin Clot Formation Homo sapiens
Defective F9 variant does not activate FX Homo sapiens
Defective cofactor function of FVIIIa variant Homo sapiens
Defective factor IX causes thrombophilia Homo sapiens
Extrinsic Pathway of Fibrin Clot Formation Homo sapiens
Gamma-carboxylation of protein precursors Homo sapiens
Intrinsic Pathway of Fibrin Clot Formation Homo sapiens
Removal of aminoterminal propeptides from gamma-carboxylated proteins Homo sapiens
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Homo sapiens
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024