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Gamma-carboxylation of protein precursors

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-159740

PubChem

R-HSA-159740

Description

Gamma-carboxylation of a cluster of glutamate residues near the amino termini of thrombin, factor VII, factor IX, factor X, protein C, protein S, protein Z, and Gas 6 is required for these proteins to bind Ca++ and function efficiently in blood clotting. A single enzyme, vitamin K-dependent gamma-carboxylase, catalyzes the gamma-carboxylation of all eight proteins involved in clotting (Morris et al. 1995; Brenner et al. 1998; Spronk et al. 2000). In the carboxylation reaction, the enzyme binds its substrate protein via a sequence motif on the amino terminal side of the glutamate residues to be carboxylated (Furie et al. 1999), then processively carboxylates all glutamates in the cluster before releasing the substrate (Morris et al. 1995; Berkner 2000; Stenina et al. 2001). The reaction occurs in the endoplasmic reticulum (Bristol et al. 1996).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 9** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P00734	Prothrombin	F2	view
P00740	Coagulation factor IX	F9	view
P00742	Coagulation factor X	F10	view
P04070	Vitamin K-dependent protein C	PROC	view
P07225	Vitamin K-dependent protein S	PROS PROS1	view
P08709	Coagulation factor VII	F7	view
P22891	Vitamin K-dependent protein Z	PROZ	view
P38435	Vitamin K-dependent gamma-carboxylase	GC GGCX	view
Q14393	Growth arrest-specific protein 6	AXLLG GAS6	view

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