Prothrombin

Summary
UniProt ID
P00734
Gene Symbol
F2
Gene ID
2147
Organism
Homo sapiens (human)
GlycoProtDB
GPDB0011275
GlyConnect
GlyGen
P00734
PubChem
P00734
The Human Metabolome Database
HMDBP13521
RaftProt
P00734
Re-Glyco
P00734
Annotation
Keyword
3D-structure Acute phase Calcium Cleavage on pair of basic residues Direct protein sequencing Disease variant Disulfide bond Gamma-carboxyglutamic acid Glycoprotein Kringle Pharmaceutical Proteomics identification Reference proteome Repeat Secreted Serine protease Signal Thrombophilia Zymogen
Gene Ontology (GO)
Displaying entries 1 - 5 of 40 in total
GO Term Evidence Code Reference
proteolysis
proteolysis
proteolysis
proteolysis
acute-phase response
GO Hierarchy
GO Hierarchy
Sequence
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
Glycosylation Sites
Displaying entries 1 - 10 of 13 in total
Position Description PubMed ID GlyTouCan ID Source
78
121
  • N-linked (GlcNAc...) (complex) asparagine
143
  • N-linked (GlcNAc...) (complex) asparagine
145
192
199
205
207
260
315
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Disease
Displaying entries 1 - 10 of 22 in total
DO ID Disease Name Source
DOID:10159 osteonecrosis
DOID:9074 systemic lupus erythematosus
DOID:12134 factor VIII deficiency
DOID:10608 celiac disease
DOID:5844 myocardial infarction
DOID:2235 prothrombin deficiency
DOID:5614 eye disease
DOID:3393 coronary artery disease
DOID:2921 glomerulonephritis
DOID:10591 pre-eclampsia

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 6, 2026