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Vitamin K-dependent protein Z
Summary
- UniProt ID
- P22891
- Gene Symbol
- PROZ
- Gene ID
- 8858
- Organism
- Homo sapiens (human)
External Links
- GlyConnect
- GlyGen
- P22891
- PubChem
- P22891
- The Human Metabolome Database
- HMDBP02005
- The O-GlcNAc Database
- P22891
- Re-Glyco
- P22891
Annotation
- Keyword
- 3D-structure Alternative splicing Blood coagulation Calcium Cleavage on pair of basic residues Direct protein sequencing Disulfide bond EGF-like domain Gamma-carboxyglutamic acid Glycoprotein Hydroxylation Proteomics identification Reference proteome Repeat Secreted Serine protease homolog Signal
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| proteolysis | ||
| proteolysis | ||
| blood coagulation | ||
| blood coagulation |
GO Hierarchy
| GO Term | Evidence Code | Reference |
|---|---|---|
| obsolete extracellular space |
|
|
| endoplasmic reticulum lumen | ||
| endoplasmic reticulum lumen | ||
| Golgi lumen | ||
| Golgi lumen |
GO Hierarchy
| GO Term | Evidence Code | Reference |
|---|---|---|
| serine-type endopeptidase activity | ||
| serine-type endopeptidase activity | ||
| calcium ion binding |
GO Hierarchy
Sequence
MAGCVPLLQGLVLVLALHRVEPSVFLPASKANDVLVRWKRAGSYLLEELFEGNLEKECYEEICVYEEAREVFENEVVTDEFWRRYKGGSPCISQPCLHNGSCQDSIWGYTCTCSPGYEGSNCELAKNECHPERTDGCQHFCLPGQESYTCSCAQGYRLGEDHKQCVPHDQCACGVLTSEKRAPDLQDLPWQVKLTNSEGKDFCGGVIIRENFVLTTAKCSLLHRNITVKTYFNRTSQDPLMIKITHVHVHMRYDADAGENDLSLLELEWPIQCPGAGLPVCTPEKDFAEHLLIPRTRGLLSGWARNGTDLGNSLTTRPVTLVEGEECGQVLNVTVTTRTYCERSSVAAMHWMDGSVVTREHRGSWFLTGVLGSQPVGGQAHMVLVTKVSRYSLWFKQIMN
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 93 |
|
|
||
| 99 |
|
|
||
| 225 |
|
|
||
| 233 |
|
|
||
| 306 |
|
|
||
| 320 |
|
|||
| 332 |
|
|
||
| unknown |
|
G49108TO
G45127HA
G31189KC
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Gamma-carboxylation of protein precursors | Homo sapiens |
| Regulation of clotting cascade | Homo sapiens |
| Removal of aminoterminal propeptides from gamma-carboxylated proteins | Homo sapiens |
| Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:13241 | Behcet's disease | |
| DOID:2316 | brain ischemia |
