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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Coagulation factor X
Summary
- UniProt ID
- P00742
- Gene Symbol
-
- F10
- Organism
- Homo sapiens (human)
External Links
- GlyConnect
- GlyGen
- P00742
- PubChem
- P00742
- The Human Metabolome Database
- HMDBP02011
Annotation
- Keyword
-
- 3D-structure
- Blood coagulation
- Calcium
- Cleavage on pair of basic residues
- Direct protein sequencing
- Disease variant
- Disulfide bond
- EGF-like domain
- Gamma-carboxyglutamic acid
- Glycoprotein
- Hydroxylation
- Reference proteome
- Repeat
- Secreted
- Serine protease
- Signal
- Zymogen
- Gene Ontology (GO)
| GO Term |
|---|
| positive regulation of leukocyte chemotaxis |
| proteolysis |
| blood coagulation |
| positive regulation of cell migration |
| positive regulation of TOR signaling |
| GO Term |
|---|
| endoplasmic reticulum lumen |
| Golgi lumen |
| external side of plasma membrane |
| extracellular region |
| extracellular space |
| plasma membrane |
| GO Term |
|---|
| serine-type endopeptidase activity |
| phospholipid binding |
| calcium ion binding |
Sequence
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
Glycosylation Sites
G43417UB
G57321FI
G80111QD
G81006GJ
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Common Pathway of Fibrin Clot Formation | Homo sapiens |
| Defective F9 variant does not activate FX | Homo sapiens |
| Defective cofactor function of FVIIIa variant | Homo sapiens |
| Defective factor IX causes thrombophilia | Homo sapiens |
| Extrinsic Pathway of Fibrin Clot Formation | Homo sapiens |
| Gamma-carboxylation of protein precursors | Homo sapiens |
| Intrinsic Pathway of Fibrin Clot Formation | Homo sapiens |
| Removal of aminoterminal propeptides from gamma-carboxylated proteins | Homo sapiens |
| Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus | Homo sapiens |
