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Antithrombin-III

Summary

UniProt ID: P01008
Gene Symbol: SERPINC1 AT3 PRO0309
Gene ID: 462
Organism: Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011285

GlyConnect

Antithrombin-III

GlyGen

P01008

PubChem

P01008

The Human Metabolome Database

HMDBP01724

RaftProt

P01008

Re-Glyco

P01008

Annotation

Keyword: 3D-structure Direct protein sequencing Disease variant Disulfide bond Glycoprotein Heparin-binding Phosphoprotein Proteomics identification Reference proteome Secreted Serine protease inhibitor Signal Thrombophilia

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	Reference
blood coagulation	TAS	Reactome
regulation of blood coagulation	IEA	GO_REF

GO Hierarchy

biological process

multicellular organismal process [inference]

coagulation [inference]

blood coagulation

biological regulation [inference]

regulation of biological process [inference]

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of blood coagulation

regulation of response to stress [inference]

regulation of response to wounding [inference]

regulation of wound healing [inference]

regulation of blood coagulation

regulation of multicellular organismal process [inference]

regulation of coagulation [inference]

regulation of blood coagulation

regulation of hemostasis [inference]

regulation of blood coagulation

regulation of biological quality [inference]

regulation of body fluid levels [inference]

hemostasis [inference]

blood coagulation

regulation of hemostasis [inference]

regulation of blood coagulation

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	Reference
extracellular region	NAS	PMID
extracellular region	TAS	Reactome Reactome Reactome Reactome Reactome Reactome
extracellular region	IDA	PMID
extracellular region	IEA	GO_REF
extracellular region	HDA	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane [inference]

plasma membrane

external encapsulating structure [inference]

extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

blood microparticle

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
protease binding	IPI	PMID
serine-type endopeptidase inhibitor activity	NAS	PMID
serine-type endopeptidase inhibitor activity	TAS	Reactome
serine-type endopeptidase inhibitor activity	IBA	GO_REF
serine-type endopeptidase inhibitor activity	IEA	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

enzyme binding [inference]

protease binding

identical protein binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MYSNVIGTVTSGKRKVYLLSLLLIGFWDCVTCHGSPVDICTAKPRDIPMNPMCIYRSPEKKATEDEGSEQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 7** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
128	N-linked (GlcNAc...) asparagine	14760718 16335952 19159218 23090970 24279413 24530628 29391424 29671580 29741879 30237853 32125861 34725484 37074911	G53075ES G94665LC G11115RO G56518TU G63136LV G78649WQ G15169WU G70232NH G14547CB G81124ET G70888PK G06247RL G47518TP G57776ZS G99668VU G86880BF G27947YN G30248BL G20528HD G63980BQ G04854VP G94470IW G34989PA G40834TG G22310AV G45395BF G88374WZ G85554PZ G43223CG G58954YZ G37412TK G31986NC G26330YA G10846ZT G40574BA G82830MN G78787DI G00273SJ G08918WF G75983OB G00912UN G42358LZ G48414YA G58087IP G11911BT G92551JA G36442WJ G27126ED G04657PL G27058EU G96091TT G86182NS G72747WU G70619PT G06356OH G37868ZX G59626AS G92406TI G45504EY G72790NZ G10486CT G95865ZB G22572EH G57776ZU G28681TP G37995HC G89045VA	GlycoProtDB UniProt GlyGen GlyConnect
167	N-linked (GlcNAc...) asparagine			UniProt GlyGen
176				GlyGen
187	N-linked (GlcNAc...) (complex) asparagine	14760718 15084671 16335952 19159218 19838169 23090970 24279413 24530628 29391424 29671580 29741879 30237853 32125861 34725484 37074911	G13694XX G46450MZ G93656SY G06247RL G16125XL G75418YA G77669RF G27947YN G90382BL G30970QQ G63980BQ G04854VP G94470IW G40834TG G22310AV G45395BF G88374WZ G20706XG G40926MX G43223CG G49642SA G31986NC G26330YA G10846ZT G40574BA G82830MN G00273SJ G08918WF G75983OB G00912UN G42358LZ G48414YA G49906RN G58087IP G11911BT G92551JA G61256FT G87661QW G17208MA G76295SF G46691LC G27126ED G04657PL G27058EU G84452RH G41071NU G35253PZ G46902YN G72747WU G70619PT G06356OH G37868ZX G59626AS G92406TI G41840AI G01650EU G23294PN G70101JE G65092SV G90659AW G37399XV G82463GQ G10486CT G22140GZ G50045TK G28541PG G85269DF G95865ZB G39446WN G41247ZX G57776ZU G28681TP G54010QB	GlycoProtDB UniProt GlyGen GlyConnect
224	N-linked (GlcNAc...) asparagine	16263699 16335952 23090970 24841998 29671580 34725484 37074911	G45395BF G00912UN G48414YA G70619PT G59626AS G10486CT G95865ZB	GlycoProtDB UniProt GlyGen GlyConnect
418		30459171	G43417UB G29068FM	GlyGen
460		29391424	G37881RL	GlyGen GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
Amplification and propagation of coagulation cascade	Homo sapiens
Fibrin formation	Homo sapiens
Initiation of coagulation cascade	Homo sapiens
Post-translational protein phosphorylation	Homo sapiens
Regulation of IGF Activity by IGFBP	Homo sapiens
Regulation of clotting cascade	Homo sapiens

Disease

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:11247	disseminated intravascular coagulation	Alliance of Genome Resources
DOID:14115	toxic shock syndrome	Alliance of Genome Resources
DOID:3755	antithrombin III deficiency	Alliance of Genome Resources
DOID:0060903	thrombosis	Alliance of Genome Resources
DOID:8805	intermediate coronary syndrome	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements