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Keratin, type II cytoskeletal 8

Summary

UniProt ID: P05787
Gene Symbol: CYK8 KRT8
Gene ID: 3856
Organism: Homo sapiens (human)

External Links

GlyConnect

Keratin, type II cytoskeletal 8

GlyGen

P05787

PubChem

P05787

The O-GlcNAc Database

P05787

RaftProt

P05787

O-GlcNAcAtlas

P05787

Re-Glyco

P05787

Annotation

Keyword: 3D-structure Acetylation Alternative splicing Coiled coil Cytoskeleton Direct protein sequencing Disease variant Glycoprotein Host-virus interaction Intermediate filament Isopeptide bond Keratin Methylation Nucleus Phosphoprotein Proteomics identification Reference proteome Ubl conjugation

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	Reference
tumor necrosis factor-mediated signaling pathway
response to other organism
cell differentiation involved in embryonic placenta development
extrinsic apoptotic signaling pathway
hepatocyte apoptotic process

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

tumor necrosis factor-mediated signaling pathway

extrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

epithelial cell apoptotic process [inference]

hepatocyte apoptotic process

cellular developmental process [inference]

cell differentiation [inference]

cell differentiation involved in embryonic placenta development

reproductive process [inference]

developmental process involved in reproduction [inference]

cell differentiation involved in embryonic placenta development

developmental process [inference]

developmental process involved in reproduction [inference]

cell differentiation involved in embryonic placenta development

cellular developmental process [inference]

cell differentiation [inference]

cell differentiation involved in embryonic placenta development

biological process involved in interspecies interaction between organisms [inference]

response to other organism

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

tumor necrosis factor-mediated signaling pathway

extrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	Reference
nucleus	HDA	PMID
nucleoplasm	IEA	GO_REF
cytoplasm	EXP	PMID
cytoplasm	IDA	PMID PMID
cytoplasm	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane [inference]

sarcolemma

plasma membrane region [inference]

apicolateral plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

membraneless organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

intermediate filament

keratin filament

Displaying 1 entry
GO Term	Evidence Code	Reference
scaffold protein binding	IPI	PMID

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

scaffold protein binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MSIRVTQKSYKVSTSGPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGMGGITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQKTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLSELEAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLESGMQNMSIHTKTTSGYAGGLSSAYGGLTSPGLSYSLGSSFGSGAGSSSFSRTSSSRAVVVKKIETRDGKLVSESSDVLPK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 25 in total

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Position	PubMed ID	GlyTouCan ID	Source
9		G49108TO	GlyGen
13	20068230 20729549 21158410 22121020 22967762 26853435 30059200 30620550 31373491 32574038 33214551 34019948 35083852 35132862 35289036 38665916 39531497 39534244 40596516 41018975 41350704	G49108TO	GlyGen The O-GlcNAc Database GlyConnect
14		G49108TO	GlyGen
15	20068230 20729549 21158410 22121020 22967762 26853435 30059200 30620550 31373491 32574038 33214551 34019948 35083852 35132862 35289036 38665916 39531497 39534244 40596516 41018975 41350704	G49108TO	GlyGen The O-GlcNAc Database GlyConnect
24		G49108TO	GlyGen
27		G49108TO	GlyGen
34	20068230 20729549 21158410 22121020 22967762 26853435 30059200 30620550 31373491 32574038 33214551 34019948 35083852 35132862 35289036 38665916 39531497 39534244 40596516 41018975 41350704	G49108TO	GlyGen The O-GlcNAc Database
36	20068230 20729549 21158410 22121020 22967762 26853435 30059200 30620550 31373491 32574038 33214551 34019948 35083852 35132862 35289036 38665916 39531497 39534244 40596516 41018975 41350704	G49108TO	GlyGen The O-GlcNAc Database
37	20068230 20729549 21158410 22121020 22967762 26853435 30059200 30620550 31373491 32574038 33214551 34019948 35083852 35132862 35289036 38665916 39531497 39534244 40596516 41018975 41350704	G49108TO	GlyGen The O-GlcNAc Database
39	20068230 20729549 21158410 22121020 22967762 26853435 30059200 30620550 31373491 32574038 33214551 34019948 35083852 35132862 35289036 38665916 39531497 39534244 40596516 41018975 41350704	G49108TO	The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Developmental Lineage of Mammary Gland Alveolar Cells	Homo sapiens
Developmental Lineage of Mammary Gland Luminal Epithelial Cells	Homo sapiens
Formation of the cornified envelope	Homo sapiens
Keratinization	Homo sapiens

Human Protein Atlas

ENSG00000170421

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:5082	liver cirrhosis	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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External Links

Annotation

International Collaboration

Acknowledgements