GlyCosmos Portal

Submissions

Developmental Lineage of Mammary Gland Alveolar Cells

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9927426

PubChem

R-HSA-9927426

Description

Mammary gland luminal progenitor cells commit to either a ductal fate, producing ductal epithelial cells that line the mammary gland ducts, or to an alveolar fate, producing milk-secreting alveolar cells (reviewed in Visvader and Stingl 2014). NOTCH signaling, WNT signaling, and hormone receptor signaling play deciding roles in fate determination of luminal progenitors, with hormone receptor negative luminal progenitors committing to the alveolar fate and hormone receptor positive luminal progenitors committing to the ductal epithelial fate (Shehata et al. 2012, Pruitt et al. 2018, reviewed in Visvader and Stingl 2014). Hormone receptor negative luminal progenitors produce alveolar progenitors, which are likely to be hormone receptor negative (reviewed in Visvader and Stingl 2014). The commitment of luminal progenitors to alveolar fate is induced during pregnancy (reviewed in Visvader and Stingl 2014). In mice, inactivation of Notch signaling in luminal progenitor cells drives their commitment to alveolar cell identity (Wang et al. 2023). Downregulation of Notch signaling in hormone receptor-negative luminal progenitors may be due to FERMT2 (also known as Kindlin-2)-mediated downregulation of Stat3-mediated expression of Notch ligand Dll1 in myoepithelial cells (Wang et al. 2023). After cessation of lactation, alveolar cells in the mammary gland die during the involution process, however, mouse lineage tracing studies suggest that some alveolar progenitors/precursors survive the involution and function as self-renewing alveolar precursors in subsequent pregnancies (reviewed in Visvader and Stingl 2014).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 14 in total

1

2

Next ›

Last »
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P00709	Alpha-lactalbumin	LALBA LYZL7	view
P01236	Prolactin	PRL	view
P03372	Estrogen receptor	ESR ESR1 NR3A1	view
P05783	Keratin, type I cytoskeletal 18	CYK18 KRT18 PIG46	view
P05787	Keratin, type II cytoskeletal 8	CYK8 KRT8	view
P06401	Progesterone receptor	NR3C3 PGR	view
P08727	Keratin, type I cytoskeletal 19	KRT19	view
P10721	Mast/stem cell growth factor receptor Kit	KIT SCFR	view
P15941	Mucin-1	MUC1 PUM	view
P16422	Epithelial cell adhesion molecule	EPCAM GA733-2 M1S2 M4S1 MIC18 TACSTD1 TROP1	view

If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".

About Release Notes Help Feedback

Click here to visit the beta site.