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Platelet glycoprotein Ib alpha chain

Summary

UniProt ID: P07359
Gene Symbol: GP1BA
Gene ID: 2811
Organism: Homo sapiens (human)

External Links

GlyConnect

Glycocalicin

GlyGen

P07359

PubChem

P07359

The O-GlcNAc Database

P07359

RaftProt

P07359

Re-Glyco

P07359

Annotation

Keyword: 3D-structure Bernard Soulier syndrome Cell adhesion Direct protein sequencing Disease variant Disulfide bond Glycoprotein Leucine-rich repeat Phosphoprotein Proteomics identification Reference proteome Repeat Signal Sulfation Transmembrane helix von Willebrand disease

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	Reference
cell morphogenesis
cell adhesion	NAS	PMID
cell adhesion	IDA	PMID
cell surface receptor signaling pathway	TAS	PMID
blood coagulation	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

cell activation [inference]

platelet activation

cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

protein activation cascade [inference]

blood coagulation, intrinsic pathway

primary metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

protein activation cascade [inference]

blood coagulation, intrinsic pathway

intercellular transport [inference]

release of sequestered calcium ion into cytosol

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

megakaryocyte development

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

multicellular organismal process [inference]

cell activation [inference]

platelet activation

coagulation [inference]

blood coagulation

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis

anatomical structure development [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

megakaryocyte development

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

megakaryocyte development

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

intercellular transport [inference]

release of sequestered calcium ion into cytosol

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell activation [inference]

positive regulation of platelet activation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of platelet activation

negative regulation of biological process [inference]

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of blood coagulation

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

regulation of response to stress [inference]

regulation of response to wounding [inference]

regulation of wound healing [inference]

regulation of blood coagulation

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell activation [inference]

positive regulation of platelet activation

regulation of cell activation [inference]

regulation of platelet activation [inference]

positive regulation of platelet activation

positive regulation of cell activation [inference]

positive regulation of platelet activation

regulation of multicellular organismal process [inference]

regulation of coagulation [inference]

regulation of blood coagulation

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

regulation of cell activation [inference]

regulation of platelet activation [inference]

positive regulation of platelet activation

positive regulation of cell activation [inference]

positive regulation of platelet activation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of platelet activation

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

regulation of hemostasis [inference]

regulation of blood coagulation

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

regulation of biological quality [inference]

regulation of body fluid levels [inference]

hemostasis [inference]

blood coagulation

regulation of hemostasis [inference]

regulation of blood coagulation

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

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GO Term	Evidence Code	Reference
plasma membrane	TAS	PMID PMID Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome
plasma membrane	IDA	PMID
plasma membrane	IBA	GO_REF
external side of plasma membrane	IDA	PMID
external side of plasma membrane	IEA	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex [inference]

plasma membrane signaling receptor complex [inference]

glycoprotein Ib-IX-V complex

glycoprotein complex [inference]

glycoprotein Ib-IX-V complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

glycoprotein Ib-IX-V complex

cellular anatomical structure [inference]

cell surface

membrane

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane [inference]

external side of plasma membrane

Displaying **all 2** entries
GO Term	Evidence Code	Reference
thrombin-activated receptor activity	TAS	PMID PMID
signaling receptor activity	IBA	GO_REF

GO Hierarchy

molecular function

molecular transducer activity [inference]

signaling receptor activity

peptide receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

proteinase-activated receptor activity [inference]

thrombin-activated receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

proteinase-activated receptor activity [inference]

thrombin-activated receptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MPLLLLLLLLPSPLHPHPICEVSKVASHLEVNCDKRNLTALPPDLPKDTTILHLSENLLYTFSLATLMPYTRLTQLNLDRCELTKLQVDGTLPVLGTLDLSHNQLQSLPLLGQTLPALTVLDVSFNRLTSLPLGALRGLGELQELYLKGNELKTLPPGLLTPTPKLEKLSLANNNLTELPAGLLNGLENLDTLLLQENSLYTIPKGFFGSHLLPFAFLHGNPWLCNCEILYFRRWLQDNAENVYVWKQGVDVKAMTSNVASVQCDNSDKFPVYKYPGKGCPTLGDEGDTDLYDYYPEEDTEGDKVRATRTVVKFPTKAHTTPWGLFYSWSTASLDSQMPSSLHPTQESTKEQTTFPPRWTPNFTLHMESITFSKTPKSTTEPTPSPTTSEPVPEPAPNMTTLEPTPSPTTPEPTSEPAPSPTTPEPTSEPAPSPTTPEPTSEPAPSPTTPEPTPIPTIATSPTILVSATSLITPKSTFLTTTKPVSLLESTKKTIPELDQPPKLRGVLQGHLESSRNDPFLHPDFCCLLPLGFYVLGLFWLLFASVVLILLLSWVGHVKPQALDSGQGAALTTATQTTHLELQRGRQVTVPRAWLLFLRGSLPTFRSSLFLWVRPNGRVGPLVAGRRPSALSQGRGQDLLSTVSIRYSGHSL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 52 in total

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Position	Description	PubMed ID	GlyTouCan ID	Source
37	N-linked (GlcNAc...) asparagine	16263699 29391424 3497398 3571205 36740532	G16774YZ G24432GW G16150CJ G38022PE G42686NQ G56784JY G86750HK G96921ZU	UniProt GlyGen GlyConnect
129		39531497	G49108TO	The O-GlcNAc Database
130		39531497	G49108TO	The O-GlcNAc Database
175	N-linked (GlcNAc...) asparagine	3497398 3571205	G16774YZ G24432GW G16150CJ G38022PE G42686NQ G86750HK G96921ZU	UniProt GlyGen
308	O-linked (GalNAc...) threonine	3497398 3571205 36740532	G60890ZT G11457RF G46748BU G01614ZM G12396GB G65562ZE	UniProt GlyGen
316	O-linked (GalNAc...) threonine	36740532		UniProt GlyGen
320	O-linked (GalNAc...) threonine	36740532		UniProt GlyGen
321	O-linked (GalNAc...) threonine	36740532		UniProt GlyGen
328	O-linked (GalNAc...) serine	36740532		UniProt GlyGen
331	O-linked (GalNAc...) threonine	36740532		UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 10** entries
Pathway Name	Organism
Amplification and propagation of coagulation cascade	Homo sapiens
Defective F9 activation	Homo sapiens
Defective binding of VWF variant to GPIb:IX:V	Homo sapiens
Enhanced binding of GP1BA variant to VWF multimer:collagen	Homo sapiens
FXIIa, PKa activate coagulation factors	Homo sapiens
GP1b-IX-V activation signalling	Homo sapiens
Platelet Adhesion to exposed collagen	Homo sapiens
Platelet Aggregation (Plug Formation)	Homo sapiens
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Homo sapiens
Regulation of clotting cascade	Homo sapiens

Disease

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:5844	myocardial infarction	Alliance of Genome Resources
DOID:0111059	Bernard-Soulier syndrome type A2	Alliance of Genome Resources
DOID:2217	Bernard-Soulier syndrome	Alliance of Genome Resources
DOID:0050864	non-arteritic anterior ischemic optic neuropathy	Alliance of Genome Resources
DOID:0111056	platelet-type bleeding disorder 3	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

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International Collaboration

Acknowledgements