GlyCosmos Portal

Submissions

Complement C1s subcomponent

Summary

UniProt ID: P09871
Gene Symbol: C1S
Gene ID: 716
Organism: Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011462

GlyConnect

Complement C1s subcomponent

GlyGen

P09871

PubChem

P09871

The Human Metabolome Database

HMDBP07481

RaftProt

P09871

Re-Glyco

P09871

Annotation

Keyword: 3D-structure Calcium Complement pathway Direct protein sequencing Disease variant Disulfide bond EGF-like domain Ehlers-Danlos syndrome Glycoprotein Hydroxylation Metal-binding Proteomics identification Reference proteome Repeat Secreted Serine protease Signal Sushi

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	Reference
proteolysis	IEA	GO_REF
complement activation, classical pathway	NAS	PMID
complement activation, classical pathway	IDA	PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID
innate immune response

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation [inference]

complement activation, classical pathway

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

immune response [inference]

humoral immune response [inference]

complement activation [inference]

complement activation, classical pathway

innate immune response

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

immune response [inference]

humoral immune response [inference]

complement activation [inference]

complement activation, classical pathway

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

Displaying entries **1 - 5** of 11 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	Reference
extracellular region	EXP	PMID
extracellular region	NAS	PMID
extracellular region	TAS	Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome
extracellular region	IEA	GO_REF GO_REF GO_REF
complement component C1 complex	NAS	PMID

GO Hierarchy

cellular component

protein-containing complex [inference]

extracellular protein-containing complex [inference]

complement component C1 complex

cellular anatomical structure [inference]

other organism part [inference]

symbiont cell surface

blood microparticle

Displaying entries **1 - 5** of 6 in total

1

2

Next ›

Last »
GO Term	Evidence Code	Reference
serine-type endopeptidase activity	EXP	PMID PMID PMID PMID PMID PMID
serine-type endopeptidase activity	IDA	PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID
serine-type endopeptidase activity	IBA	GO_REF
serine-type endopeptidase activity	IEA	GO_REF GO_REF GO_REF
calcium ion binding	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

protein binding [inference]

identical protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQENSTPRED

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
174	N-linked (GlcNAc...) asparagine	19159218 2141278 23090970 23922389 29671580 29741879	G00912UN G48414YA G84452RH G59626AS	GlycoProtDB UniProt GlyGen GlyConnect
406	N-linked (GlcNAc...) asparagine	12788922 16335952 19159218 29741879	G94917XT G47737VJ G75983OB G00912UN G48414YA	GlycoProtDB UniProt GlyGen GlyConnect
544				GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Classical antibody-mediated complement activation	Homo sapiens
Dengue virus activates/modulates innate and adaptive immune responses	Homo sapiens
Initial triggering of complement	Homo sapiens
Regulation of Complement cascade	Homo sapiens

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080987	Ehlers-Danlos syndrome periodontal type 2	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements