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Dengue virus activates/modulates innate and adaptive immune responses

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9920588

PubChem

R-HSA-9920588

Description

Dengue virus nonstructural protein NS1 interacts with several parts of the complement system. In addition, nonstructural proteins, as well as prM and C, bind factors of the host's type I interferon antiviral response (reviewed in Ramirez & Urcuqui-Inchima, 2015; Cumberworth et al. 2017). The overall picture is known from many expression studies. For general reviews about DENV subversion of innate immunity see Kao et al., 2018; Tremblay et al., 2019; Carr et al., 2020; Kraivong et al., 2021; Pan et al., 2022. DENV also employs various strategies to evade the adaptive immune system, including antigenic variation and inhibition of antigen presentation (reviewed in Lee et al., 2022).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 24 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O00571	ATP-dependent RNA helicase DDX3X	DBX DDX3 DDX3X	view
P02647	Apolipoprotein A-I	APOA1	view
P02745	Complement C1q subcomponent subunit A	C1QA	view
P04003	C4b-binding protein alpha chain	C4BP C4BPA	view
P04004	Vitronectin	VTN	view
P07900	Heat shock protein HSP 90-alpha	HSP90A HSP90AA1 HSPC1 HSPCA	view
P08238	Heat shock protein HSP 90-beta	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	view
P09871	Complement C1s subcomponent	C1S	view
P0C0L4	Complement C4-A	C4A C4B; C4B_2 CO4 CPAMD2 CPAMD3	view
P0C0L5	Complement C4-B	C4A C4B; C4B_2 CO4 CPAMD2 CPAMD3	view

Displaying **all 4** entries
GlyCosmos Lectin	UniProt ID	Lectin Name	Pathway Viewer
GL_000190	Q9NY25	C-type lectin domain family 5 member A	view
GL_001413	P0C0L5	Complement C4-B	view
GL_002341	P11226	Mannose-binding protein C	view
GL_002853	P04004	Vitronectin	view

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