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Guidelines

MIRAGE

C-type lectin domain family 5 member A

Summary

GlyCosmos Lectin

GL_000190

Lectin Name Aliases

C-type lectin superfamily member 5
MDL-1
Myeloid DAP12-associating lectin 1

Organism

Homo sapiens (human)

External Links

UniProt: Q9NY25
UniLectin: Q9NY25

Annotation

Keyword: 3D-structure Alternative splicing Cell membrane Disulfide bond Glycoprotein Host cell receptor for virus entry Host-virus interaction Innate immunity Lectin Proteomics identification Reference proteome Signal-anchor Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	Reference
positive regulation of cytokine production	IEA	GO_REF
osteoblast development	ISS	GO_REF
osteoblast development	IEA	GO_REF
cellular defense response	TAS	PMID
signal transduction	TAS	PMID

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response

cellular process [inference]

signal transduction

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation

cell development [inference]

osteoblast development

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

osteoblast development

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation

cell development [inference]

osteoblast development

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

cellular defense response

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of myeloid cell apoptotic process

regulation of cellular process [inference]

signal transduction

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of myeloid cell apoptotic process [inference]

negative regulation of myeloid cell apoptotic process

negative regulation of apoptotic process

negative regulation of myeloid cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of myeloid cell apoptotic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of myeloid cell apoptotic process

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	Reference
cytosol
plasma membrane	EXP	PMID
plasma membrane	TAS	PMID Reactome Reactome Reactome Reactome
plasma membrane	IDA	GO_REF
plasma membrane	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

bounding membrane of organelle [inference]

secretory granule membrane [inference]

Displaying **all 4** entries
GO Term	Evidence Code	Reference
virus receptor activity	IDA	PMID
virus receptor activity	IBA	GO_REF
virus receptor activity	IEA	GO_REF GO_REF
carbohydrate binding

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

exogenous protein binding [inference]

virus receptor activity

carbohydrate binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Pathway

Displaying **all 3** entries
Pathway Name	Organism
DAP12 interactions	Homo sapiens
Dengue virus activates/modulates innate and adaptive immune responses	Homo sapiens
Neutrophil degranulation	Homo sapiens

UniLectin

UniProt
Q9NY25

PDB

2YHF

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026