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Neurogenic locus protein delta

Summary

UniProt ID: P10041
Gene Symbol: CG3619 Delta Dl
Gene ID: 42313
Organism: Drosophila melanogaster (fruit fly)

External Links

PubChem: P10041
Re-Glyco: P10041

Annotation

Keyword: 3D-structure Cell membrane Cytoplasm Developmental protein Differentiation Disulfide bond EGF-like domain Endosome Glycoprotein Neurogenesis Notch signaling pathway Phosphoprotein Reference proteome Repeat Signal Transmembrane helix Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 5** of 48 in total

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GO Term	Evidence Code	Reference
cell fate specification	TAS	PMID
actin filament organization	IMP	PMID
Notch signaling pathway	IDA	PMID PMID
Notch signaling pathway	IMP	PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID PMID
Notch signaling pathway	IGI	PMID PMID PMID PMID

GO Hierarchy

biological process

cellular process [inference]

cell cycle [inference]

mitotic cell cycle [inference]

second mitotic wave involved in compound eye morphogenesis

cell communication [inference]

cell-cell signaling [inference]

cell-cell signaling involved in cell fate commitment [inference]

lateral inhibition

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

cell death [inference]

programmed cell death [inference]

programmed cell death involved in cell development [inference]

retinal cell programmed cell death [inference]

compound eye retinal cell programmed cell death

cellular process involved in reproduction in multicellular organism [inference]

germ cell development [inference]

oogenesis

cellular developmental process [inference]

cell fate specification

neuron fate specification

cell fate determination [inference]

neuroblast fate determination

programmed cell death involved in cell development [inference]

retinal cell programmed cell death [inference]

compound eye retinal cell programmed cell death

cell differentiation [inference]

neuron differentiation [inference]

photoreceptor cell differentiation [inference]

eye photoreceptor cell differentiation [inference]

compound eye photoreceptor cell differentiation [inference]

stem cell differentiation

cell development [inference]

epithelial cell development [inference]

follicle cell of egg chamber development

germ cell development [inference]

oogenesis

neuron development [inference]

photoreceptor cell development [inference]

eye photoreceptor cell development [inference]

compound eye photoreceptor development

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

epithelial cell migration [inference]

follicle cell of egg chamber migration [inference]

border follicle cell migration

glial cell migration

cell division [inference]

asymmetric cell division

localization of cell [inference]

oocyte localization involved in germarium-derived egg chamber formation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

supramolecular fiber organization [inference]

actin filament organization

reproductive process [inference]

developmental process involved in reproduction [inference]

germ cell development [inference]

oogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

female gamete generation [inference]

oogenesis

cellular process involved in reproduction in multicellular organism [inference]

germ cell development [inference]

oogenesis

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

imaginal disc pattern formation [inference]

anterior/posterior pattern specification, imaginal disc [inference]

wing disc anterior/posterior pattern formation

dorsal/ventral pattern formation, imaginal disc [inference]

wing disc dorsal/ventral pattern formation

wing disc pattern formation [inference]

anterior/posterior pattern specification [inference]

anterior/posterior pattern specification, imaginal disc [inference]

wing disc anterior/posterior pattern formation

dorsal/ventral pattern formation [inference]

dorsal/ventral pattern formation, imaginal disc [inference]

wing disc dorsal/ventral pattern formation

segmentation [inference]

appendage segmentation [inference]

imaginal disc-derived leg segmentation

stem cell population maintenance [inference]

germ-line stem cell population maintenance

developmental process [inference]

developmental process involved in reproduction [inference]

germ cell development [inference]

oogenesis

anatomical structure morphogenesis [inference]

cell morphogenesis [inference]

follicle cell of egg chamber stalk formation

post-embryonic animal morphogenesis [inference]

post-embryonic appendage morphogenesis [inference]

antennal morphogenesis

animal organ morphogenesis [inference]

chaeta morphogenesis

appendage morphogenesis [inference]

imaginal disc-derived appendage morphogenesis [inference]

post-embryonic appendage morphogenesis [inference]

antennal morphogenesis

anatomical structure development [inference]

tissue development [inference]

mesoderm development

cell development [inference]

epithelial cell development [inference]

follicle cell of egg chamber development

germ cell development [inference]

oogenesis

neuron development [inference]

photoreceptor cell development [inference]

eye photoreceptor cell development [inference]

compound eye photoreceptor development

animal organ development [inference]

sensory organ development

system development [inference]

peripheral nervous system development

cellular developmental process [inference]

cell fate specification

neuron fate specification

cell fate determination [inference]

neuroblast fate determination

programmed cell death involved in cell development [inference]

retinal cell programmed cell death [inference]

compound eye retinal cell programmed cell death

cell differentiation [inference]

neuron differentiation [inference]

photoreceptor cell differentiation [inference]

eye photoreceptor cell differentiation [inference]

compound eye photoreceptor cell differentiation [inference]

stem cell differentiation

cell development [inference]

epithelial cell development [inference]

follicle cell of egg chamber development

germ cell development [inference]

oogenesis

neuron development [inference]

photoreceptor cell development [inference]

eye photoreceptor cell development [inference]

compound eye photoreceptor development

maintenance of cell number [inference]

stem cell population maintenance [inference]

germ-line stem cell population maintenance

localization [inference]

localization of cell [inference]

oocyte localization involved in germarium-derived egg chamber formation

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

negative regulation of Notch signaling pathway

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

signaling [inference]

cell-cell signaling [inference]

cell-cell signaling involved in cell fate commitment [inference]

lateral inhibition

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

negative regulation of Notch signaling pathway

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of animal organ morphogenesis [inference]

regulation of establishment of planar polarity

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

negative regulation of Notch signaling pathway

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle

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GO Term	Evidence Code	Reference
endosome	IDA	PMID
early endosome	IDA	PMID
plasma membrane	TAS	Reactome
plasma membrane	IDA	PMID PMID PMID PMID PMID
plasma membrane	IBA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm [inference]

cell cortex [inference]

cell cortex region [inference]

apical cortex

cytoplasmic region [inference]

cell cortex region [inference]

apical cortex

cell surface

membrane

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endosome

early endosome

endocytic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endosome

early endosome

endocytic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endosome

early endosome

endocytic vesicle

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
Notch binding	IDA	PMID PMID PMID PMID PMID
Notch binding	IBA	GO_REF
Notch binding	IPI	PMID PMID PMID
calcium ion binding	IEA	GO_REF
glycosphingolipid binding	IDA	PMID

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

Notch binding

lipid binding [inference]

sphingolipid binding [inference]

glycosphingolipid binding

glycolipid binding [inference]

glycosphingolipid binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

carbohydrate derivative binding [inference]

glycolipid binding [inference]

glycosphingolipid binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MHWIKCLLTAFICFTVIVQVHSSGSFELRLKYFSNDHGRDNEGRCCSGESDGATGKCLGSCKTRFRVCLKHYQATIDTTSQCTYGDVITPILGENSVNLTDAQRFQNKGFTNPIQFPFSFSWPGTFSLIVEAWHDTNNSGNARTNKLLIQRLLVQQVLEVSSEWKTNKSESQYTSLEYDFRVTCDLNYYGSGCAKFCRPRDDSFGHSTCSETGEIICLTGWQGDYCHIPKCAKGCEHGHCDKPNQCVCQLGWKGALCNECVLEPNCIHGTCNKPWTCICNEGWGGLYCNQDLNYCTNHRPCKNGGTCFNTGEGLYTCKCAPGYSGDDCENEIYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLTCSDKPCHQGICRNVRPGLGSKGQGYQCECPIGYSGPNCDLQLDNCSPNPCINGGSCQPSGKCICPAGFSGTRCETNIDDCLGHQCENGGTCIDMVNQYRCQCVPGFHGTHCSSKVDLCLIRPCANGGTCLNLNNDYQCTCRAGFTGKDCSVDIDECSSGPCHNGGTCMNRVNSFECVCANGFRGKQCDEESYDSVTFDAHQYGATTQARADGLTNAQVVLIAVFSVAMPLVAVIAACVVFCMKRKRKRAQEKDDAEARKQNEQNAVATMHHNGSGVGVALASASLGGKTGSNSGLTFDGGNPNIIKNTWDKSVNNICASAAAAAAAAAAADECLMYGGYVASVADNNNANSDFCVAPLQRAKSQKQLNTDPTLMHRGSPAGSSAKGASGGGPGAAEGKRISVLGEGSYCSQRWPSLAAAGVAGACSSQLMAAASVAGSGAGTAQQQRSVVCGTPHM

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	Source
98	N-linked (GlcNAc...) asparagine	UniProt
137	N-linked (GlcNAc...) asparagine	UniProt
167	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
NOTCH2 Activation and Transmission of Signal to the Nucleus	Drosophila melanogaster

Disease

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:12930	dilated cardiomyopathy	Alliance of Genome Resources
DOID:162	cancer	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements