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MIRAGE

delta

Summary

Gene Symbol

Delta

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

42313

KEGG Gene ID

PubChem

42313

Alliance of Genome Resources

FB:FBgn0000463

Annotation

Keyword

3D-structure
Cell membrane
Cytoplasm
Developmental protein
Differentiation
Disulfide bond
EGF-like domain
Endosome
Glycoprotein
Neurogenesis
Notch signaling pathway
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P10041
A4V346

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 56 in total

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GO Term	Evidence Code	PMID
cell morphogenesis	IEA
cell fate specification	TAS
actin filament organization	IMP
cell communication	IEA
Notch signaling pathway	IDA

GO Hierarchy

biological process

cellular process [inference]

cell cycle [inference]

mitotic cell cycle [inference]

second mitotic wave involved in compound eye morphogenesis

cell communication

cell-cell signaling [inference]

cell-cell signaling involved in cell fate commitment [inference]

lateral inhibition

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

cell death [inference]

programmed cell death [inference]

programmed cell death involved in cell development [inference]

retinal cell programmed cell death [inference]

compound eye retinal cell programmed cell death

cellular process involved in reproduction in multicellular organism [inference]

germ cell development [inference]

oogenesis

cellular developmental process [inference]

cell fate specification

neuron fate specification

cell fate determination [inference]

neuroblast fate determination

programmed cell death involved in cell development [inference]

retinal cell programmed cell death [inference]

compound eye retinal cell programmed cell death

cell differentiation [inference]

neurogenesis [inference]

gliogenesis

neuron differentiation [inference]

photoreceptor cell differentiation [inference]

eye photoreceptor cell differentiation [inference]

compound eye photoreceptor cell differentiation [inference]

stem cell differentiation

cell development [inference]

epithelial cell development [inference]

follicle cell of egg chamber development

germ cell development [inference]

oogenesis

neuron development

photoreceptor cell development [inference]

eye photoreceptor cell development [inference]

compound eye photoreceptor development

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

epithelial cell migration [inference]

follicle cell of egg chamber migration [inference]

border follicle cell migration

glial cell migration

cell division [inference]

asymmetric cell division

localization of cell [inference]

oocyte localization involved in germarium-derived egg chamber formation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

supramolecular fiber organization [inference]

actin filament organization

reproductive process [inference]

developmental process involved in reproduction [inference]

germ cell development [inference]

oogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

female gamete generation [inference]

oogenesis

cellular process involved in reproduction in multicellular organism [inference]

germ cell development [inference]

oogenesis

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

imaginal disc pattern formation [inference]

anterior/posterior pattern specification, imaginal disc [inference]

wing disc anterior/posterior pattern formation

dorsal/ventral pattern formation, imaginal disc [inference]

wing disc dorsal/ventral pattern formation

wing disc pattern formation [inference]

anterior/posterior pattern specification [inference]

anterior/posterior pattern specification, imaginal disc [inference]

wing disc anterior/posterior pattern formation

dorsal/ventral pattern formation [inference]

dorsal/ventral pattern formation, imaginal disc [inference]

wing disc dorsal/ventral pattern formation

segmentation [inference]

appendage segmentation [inference]

imaginal disc-derived leg segmentation

stem cell population maintenance [inference]

germ-line stem cell population maintenance

developmental process [inference]

developmental process involved in reproduction [inference]

germ cell development [inference]

oogenesis

anatomical structure morphogenesis [inference]

cell morphogenesis

follicle cell of egg chamber stalk formation

post-embryonic animal morphogenesis [inference]

post-embryonic appendage morphogenesis [inference]

antennal morphogenesis

animal organ morphogenesis [inference]

chaeta morphogenesis

appendage morphogenesis [inference]

imaginal disc-derived appendage morphogenesis [inference]

post-embryonic appendage morphogenesis [inference]

antennal morphogenesis

anatomical structure formation involved in morphogenesis

anatomical structure development [inference]

tissue development [inference]

cell development [inference]

epithelial cell development [inference]

follicle cell of egg chamber development

germ cell development [inference]

oogenesis

neuron development

photoreceptor cell development [inference]

eye photoreceptor cell development [inference]

compound eye photoreceptor development

animal organ development [inference]

sensory organ development

imaginal disc development [inference]

eye-antennal disc development

system development [inference]

peripheral nervous system development

cellular developmental process [inference]

cell fate specification

neuron fate specification

cell fate determination [inference]

neuroblast fate determination

programmed cell death involved in cell development [inference]

retinal cell programmed cell death [inference]

compound eye retinal cell programmed cell death

cell differentiation [inference]

neurogenesis [inference]

gliogenesis

neuron differentiation [inference]

photoreceptor cell differentiation [inference]

eye photoreceptor cell differentiation [inference]

compound eye photoreceptor cell differentiation [inference]

stem cell differentiation

cell development [inference]

epithelial cell development [inference]

follicle cell of egg chamber development

germ cell development [inference]

oogenesis

neuron development

photoreceptor cell development [inference]

eye photoreceptor cell development [inference]

compound eye photoreceptor development

maintenance of cell number [inference]

stem cell population maintenance [inference]

germ-line stem cell population maintenance

localization [inference]

localization of cell [inference]

oocyte localization involved in germarium-derived egg chamber formation

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

negative regulation of Notch signaling pathway

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

signaling [inference]

cell-cell signaling [inference]

cell-cell signaling involved in cell fate commitment [inference]

lateral inhibition

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

negative regulation of Notch signaling pathway

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

regulation of developmental process

regulation of anatomical structure morphogenesis [inference]

regulation of animal organ morphogenesis [inference]

regulation of establishment of planar polarity

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

negative regulation of Notch signaling pathway

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
endosome	IDA
early endosome	IDA
multivesicular body	IEA
plasma membrane	TAS
plasma membrane	IDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm [inference]

cell cortex region [inference]

apical cortex

cytoplasmic region [inference]

cell cortex region [inference]

apical cortex

cell surface

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

endosome membrane

plasma membrane region [inference]

apical plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

early endosome

late endosome [inference]

multivesicular body

endocytic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

early endosome

late endosome [inference]

multivesicular body

endocytic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

early endosome

late endosome [inference]

multivesicular body

endocytic vesicle

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
Notch binding	IDA
Notch binding	IBA
Notch binding	IPI
calcium ion binding	IEA
protein binding	IPI

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

Notch binding

lipid binding [inference]

sphingolipid binding [inference]

glycosphingolipid binding

glycolipid binding [inference]

glycosphingolipid binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

carbohydrate derivative binding [inference]

glycolipid binding [inference]

glycosphingolipid binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Delta-like protein

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
Notch binding
calcium ion binding
cell communication
negative regulation of Notch signaling pathway

Displaying **all 8** entries
InterPro
Delta/Serrate/lag-2 (DSL) protein
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
EGF-like, conserved site
EGF-type aspartate/asparagine hydroxylation site
Growth factor receptor cysteine-rich domain superfamily
Notch ligand, N-terminal domain

Alliance of Genome Resources

Expression

Displaying **all 10** entries
Location	References
plasma membrane	PMID:12747835 PMID:16459304 PMID:16643882 PMID:17065551 PMID:2185893
endocytic vesicle	PMID:17028337
cell surface	PMID:14627723 PMID:20203305
membrane	PMID:15611340
intracellular anatomical structure	PMID:12747835
endosome	PMID:19295516
early endosome	PMID:14627723
cytoplasmic vesicle	PMID:16137928 PMID:17065551
cytoplasm	PMID:1383233
apical cortex	PMID:15760269

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:12930	dilated cardiomyopathy	Alliance of Genome Resources
DOID:162	cancer	Alliance of Genome Resources

Ortholog

Displaying **all 9** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	54485	MGI:1859388
Mus musculus	13388	MGI:104659
Rattus norvegicus	311332	RGD:1309740
Rattus norvegicus	84010	RGD:70949
Caenorhabditis elegans	178759	WB:WBGene00000168
Homo sapiens	54567	HGNC:2910
Homo sapiens	28514	HGNC:2908
Danio rerio	30120	ZFIN:ZDB-GENE-000125-4
Danio rerio	30141	ZFIN:ZDB-GENE-980526-114

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026