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Inter-alpha-trypsin inhibitor heavy chain H2

Summary

UniProt ID: P19823
Gene Symbol: ITIH2 IGHEP2
Gene ID: 3698
Organism: Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011594

GlyConnect

Inter-alpha-trypsin inhibitor heavy chain h2

GlyGen

P19823

PubChem

P19823

The O-GlcNAc Database

P19823

RaftProt

P19823

Re-Glyco

P19823

Annotation

Keyword: Direct protein sequencing Disulfide bond Gamma-carboxyglutamic acid Phosphoprotein Proteoglycan Proteomics identification Reference proteome Secreted Serine protease inhibitor Signal

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	Reference
hyaluronan metabolic process	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

glycosaminoglycan metabolic process [inference]

hyaluronan metabolic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

glycosaminoglycan metabolic process [inference]

hyaluronan metabolic process

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
extracellular region	NAS	PMID
extracellular region	IEA	GO_REF
endoplasmic reticulum lumen	TAS	Reactome
extracellular matrix	HDA	PMID PMID PMID
extracellular exosome	HDA	PMID PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

blood microparticle

Displaying **all 3** entries
GO Term	Evidence Code	Reference
endopeptidase inhibitor activity	TAS	PMID
serine-type endopeptidase inhibitor activity	IEA	GO_REF
hyaluronic acid binding	IDA	PMID

GO Hierarchy

molecular function

binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

hyaluronic acid binding

organic acid binding [inference]

carboxylic acid binding [inference]

hyaluronic acid binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MKRLTCFFICFFLSEVSGFEIPINGLSEFVDYEDLVELAPGKFQLVAENRRYQRSLPGESEEMMEEVDQVTLYSYKVQSTITSRMATTMIQSKVVNNSPQPQNVVFDVQIPKGAFISNFSMTVDGKTFRSSIKEKTVGRALYAQARAKGKTAGLVRSSALDMENFRTEVNVLPGAKVQFELHYQEVKWRKLGSYEHRIYLQPGRLAKHLEVDVWVIEPQGLRFLHVPDTFEGHFDGVPVISKGQQKAHVSFKPTVAQQRICPNCRETAVDGELVVLYDVKREEKAGELEVFNGYFVHFFAPDNLDPIPKNILFVIDVSGSMWGVKMKQTVEAMKTILDDLRAEDHFSVIDFNQNIRTWRNDLISATKTQVADAKRYIEKIQPSGGTNINEALLRAIFILNEANNLGLLDPNSVSLIILVSDGDPTVGELKLSKIQKNVKENIQDNISLFSLGMGFDVDYDFLKRLSNENHGIAQRIYGNQDTSSQLKKFYNQVSTPLLRNVQFNYPHTSVTDVTQNNFHNYFGGSEIVVAGKFDPAKLDQIESVITATSANTQLVLETLAQMDDLQDFLSKDKHADPDFTRKLWAYLTINQLLAERSLAPTAAAKRRITRSILQMSLDHHIVTPLTSLVIENEAGDERMLADAPPQDPSCCSGALYYGSKVVPDSTPSWANPSPTPVISMLAQGSQVLESTPPPHVMRVENDPHFIIYLPKSQKNICFNIDSEPGKILNLVSDPESGIVVNGQLVGAKKPNNGKLSTYFGKLGFYFQSEDIKIEISTETITLSHGSSTFSLSWSDTAQVTNQRVQISVKKEKVVTITLDKEMSFSVLLHRVWKKHPVNVDFLGIYIPPTNKFSPKAHGLIGQFMQEPKIHIFNERPGKDPEKPEASMEVKGQKLIITRGLQKDYRTDLVFGTDVTCWFVHNSGKGFIDGHYKDYFVPQLYSFLKRP

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 18 in total

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Position	Description	PubMed ID	GlyTouCan ID	Source
96		37074911	G40574BA G00912UN	GlyGen
118	N-linked (GlcNAc...) (complex) asparagine	12754519 16335952 19159218 23090970 29391424 29671580 29741879 37074911 9425062 9677337	G90787TS G38663NM G37881RL G63980BQ G04854VP G94470IW G40834TG G45395BF G07246CJ G85554PZ G43223CG G58954YZ G31986NC G26330YA G10846ZT G40574BA G82830MN G08918WF G47737VJ G75983OB G00912UN G42358LZ G48414YA G95660LN G11911BT G46691LC G04657PL G46524LG G41071NU G72747WU G70619PT G06356OH G59626AS G65835SY G08290VR G01650EU G37399XV G10486CT G22140GZ G50045TK G95865ZB G06110VR G28681TP G37995HC	GlycoProtDB UniProt GlyGen GlyConnect
445	N-linked (GlcNAc...) asparagine	16335952		UniProt GlyGen
482		30397120 37340703 38665916	G49108TO	The O-GlcNAc Database
483		30397120 37340703 38665916	G49108TO	The O-GlcNAc Database
484		30397120 37340703 38665916	G49108TO	The O-GlcNAc Database
601		23584533	G57321FI	GlyGen
652		30459171	G43417UB	GlyGen
665		22171320	G57317CE	GlyGen
666	O-linked (GalNAc...) threonine; partial	22171320 9425062 9677337	G57317CE G63110FE G10225UW G74722FL G98535LH	UniProt GlyGen GlyConnect