Transcobalamin-1

Summary
UniProt ID
P20061
Gene Symbol
  • TC1
  • TCN1
Gene ID
6947
Organism
Homo sapiens (human)
GlyConnect
GlyGen
P20061
PubChem
P20061
The Human Metabolome Database
HMDBP01996
Re-Glyco
P20061
Annotation
Keyword
  • 3D-structure
  • Cobalt transport
  • Disulfide bond
  • Glycoprotein
  • Reference proteome
  • Secreted
  • Signal
Gene Ontology (GO)
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying all 2 entries
GO Term
cobalt ion transport
cobalamin transport
Sequence
MRQSHQLPLVGLLLFSFIPSQLCEICEVSEENYIRLKPLLNTMIQSNYNRGTSAVNVVLSLKLVGIQIQTLMQKMIQQIKYNVKSRLSDVSSGELALIILALGVCRNAEENLIYDYHLIDKLENKFQAEIENMEAHNGTPLTNYYQLSLDVLALCLFNGNYSTAEVVNHFTPENKNYYFGSQFSVDTGAMAVLALTCVKKSLINGQIKADEGSLKNISIYTKSLVEKILSEKKENGLIGNTFSTGEAMQALFVSSDYYNENDWNCQQTLNTVLTEISQGAFSNPNAAAQVLPALMGKTFLDINKDSSCVSASGNFNISADEPITVTPPDSQSYISVNYSVRINETYFTNVTVLNGSVFLSVMEKAQKMNDTIFGFTMEERSWGPYITCIQGLCANNNDRTYWELLSGGEPLSQGAGSYVVRNGENLEVRWSKY
Glycosylation Sites
Displaying all 9 entries
Position Description PubMed ID GlyTouCan ID Source
160 N-linked (GlcNAc...) asparagine
216 N-linked (GlcNAc...) asparagine
314
316 N-linked (GlcNAc...) asparagine
337 N-linked (GlcNAc...) asparagine
343 N-linked (GlcNAc...) asparagine
349 N-linked (GlcNAc...) asparagine
354 N-linked (GlcNAc...) asparagine
369 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 3 entries
Pathway Name Organism
Neutrophil degranulation Homo sapiens
Transport of RCbl within the body Homo sapiens
Uptake of dietary cobalamins into enterocytes Homo sapiens

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 4, 2025