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Transport of RCbl within the body

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9758890

PubChem

R-HSA-9758890

Description

The steps of transport of cobalamins (RCbl) from the enterocyte to the cells in which it will function as a cofactor, together with its reuptake in the renal tubule, are annotated here. While methylcobalamin is the predominant cobalamin in the blood (Chu et al. 1993), other cobalamins including cyanocobalamin and adenosylcobalamin are also present and the proteins involved in these processes accommodate all of them (Banerjee et al. 2021; Nielsen et al. 2012; Quadros 2010). This broad specificity is indicated by annotating R-cob(III)alamin (RCbl - CHEBI:140785) as the cargo in all of these processes.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 5** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P20061	Transcobalamin-1	TC1 TCN1	view
P33527	Multidrug resistance-associated protein 1	ABCC1 MRP MRP1	view
P98164	Low-density lipoprotein receptor-related protein 2	LRP2	view
Q9NPF0	CD320 antigen	8D6A CD320 UNQ198/PRO224	view
Q9NUN5	Lysosomal cobalamin transport escort protein LMBD1	BM-021 C6orf209 CD001 LMBRD1 MSTP044 NESI	view

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