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MIRAGE
Neurotrophic factor BDNF precursor form
Summary
- UniProt ID
- P23363
- Gene Symbol
- Bdnf
- Gene ID
- 24225
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
- Cleavage on pair of basic residues Disulfide bond Glycoprotein Growth factor Reference proteome Secreted Signal
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| ureteric bud development | ||
| behavioral fear response | ||
| response to hypoxia | ||
| chronic inflammatory response | ||
| mitochondrial electron transport, NADH to ubiquinone |
GO Hierarchy
biological process
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of metabolic process [inference]
regulation of programmed cell death [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cellular component organization [inference]
regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | Reference |
|---|---|---|
| extracellular region | ||
| extracellular region | ||
| extracellular region | ||
| extracellular region | ||
| extracellular region |
| GO Term | Evidence Code | Reference |
|---|---|---|
| nerve growth factor receptor binding | ||
| neurotrophin TRKB receptor binding | ||
| growth factor activity | ||
| growth factor activity |
Sequence
MTILFLTMVISYFGCMKAAPMKEANVHGQGNLAYPAVRTHGTLESVNGPRAGSRGLTTTSLADTFEHVIEELLDEDQKVRPNEENHKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCTLTIKRGR
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 123 |
|
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activated NTRK2 signals through FRS2 and FRS3 | Rattus norvegicus |
| Activated NTRK2 signals through PLCG1 | Rattus norvegicus |
| NTRK2 activates RAC1 | Rattus norvegicus |
| PI3K/AKT Signaling | Rattus norvegicus |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | Rattus norvegicus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050741 | alcohol dependence | |
| DOID:8466 | retinal degeneration | |
| DOID:1686 | glaucoma | |
| DOID:10652 | Alzheimer's disease | |
| DOID:1824 | status epilepticus | |
| DOID:9743 | diabetic neuropathy | |
| DOID:1679 | cystitis | |
| DOID:11446 | sciatic neuropathy |
