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Phosphatidylinositol 3-kinase regulatory subunit alpha

Summary

UniProt ID

P26450

Gene Symbol

Pik3r1

Gene ID

18708

Organism

Mus musculus (house mouse)

External Links

GlyGen: P26450
PubChem: P26450
O-GlcNAcAtlas: P26450
Re-Glyco: P26450

Annotation

Keyword

Acetylation
Direct protein sequencing
Phosphoprotein
Protein transport
Reference proteome
Repeat
SH2 domain
SH3 domain
Stress response
Ubl conjugation

Gene Ontology (GO)

Displaying **all 10** entries
GO Term
perinuclear endoplasmic reticulum membrane
phosphatidylinositol 3-kinase complex, class IA
nucleus
cytoplasm
cell-cell junction
membrane
cytosol
perinuclear region of cytoplasm
cis-Golgi network
phosphatidylinositol 3-kinase complex

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 37 in total

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GO Term
positive regulation of leukocyte migration
negative regulation of cell adhesion
B cell differentiation
osteoclast differentiation
negative regulation of apoptotic process
negative regulation of osteoclast differentiation
myeloid leukocyte migration
response to endoplasmic reticulum stress
interleukin-18-mediated signaling pathway
regulation of stress fiber assembly

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GO Term
insulin binding
insulin receptor substrate binding
phosphotyrosine residue binding
insulin-like growth factor receptor binding
neurotrophin TRKA receptor binding
phosphatidylinositol 3-kinase regulator activity
phosphatidylinositol 3-kinase regulatory subunit binding
ErbB-3 class receptor binding
1-phosphatidylinositol-3-kinase regulator activity
insulin receptor binding

Annotation information from UniProt.

Sequence

MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEDIGWLNGYNETTGERGDFPGTYVEYIGRKRISPPTPKPRPPRPLPVAPGSSKTEADTEQQALPLPDLAEQFAPPDVAPPLLIKLLEAIEKKGLECSTLYRTQSSSNPAELRQLLDCDAASVDLEMIDVHVLADAFKRYLADLPNPVIPVAVYNEMMSLAQELQSPEDCIQLLKKLIRLPNIPHQCWLTLQYLLKHFFKLSQASSKNLLNARVLSEIFSPVLFRFPAASSDNTEHLIKAIEILISTEWNERQPAPALPPKPPKPTTVANNSMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNHDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
541			G49108TO	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 55 in total

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Pathway Name	Organism
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Mus musculus
CD28 dependent PI3K/Akt signaling	Mus musculus
CDC42 GTPase cycle	Mus musculus
Costimulation by the CD28 family	Mus musculus
DAP12 signaling	Mus musculus
Downstream TCR signaling	Mus musculus
Downstream signal transduction	Mus musculus
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	Mus musculus
Extra-nuclear estrogen signaling	Mus musculus
FLT3 Signaling	Mus musculus

Disease

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0111454	SHORT syndrome	Alliance of Genome Resources
DOID:14179	X-linked agammaglobulinemia	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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External Links

Annotation

International Collaboration

Acknowledgements