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Genome polyprotein

Summary

UniProt ID

P27958

Gene Symbol

Organism

Hepatitis C virus (isolate H77)

External Links

GlyGen: P27958
PubChem: P27958
Re-Glyco: P27958

Annotation

Keyword

3D-structure
Acetylation
Activation of host autophagy by virus
Apoptosis
Capsid protein
Clathrin-mediated endocytosis of virus by host
Direct protein sequencing
Disulfide bond
Fusion of virus membrane with host endosomal membrane
G1/S host cell cycle checkpoint dysregulation by virus
Glycoprotein
Helicase
Host cell membrane
Host cytoplasm
Host endoplasmic reticulum
Host lipid droplet
Host mitochondrion
Host nucleus
Inhibition of host MAVS by virus
Inhibition of host STAT1 by virus
Inhibition of host TRAFs by virus
Isopeptide bond
Magnesium
Metal-binding
Multifunctional enzyme
Oncogene
Palmitate
Phosphoprotein
RNA-binding
RNA-directed RNA polymerase
Reference proteome
Ribonucleoprotein
Ribosomal frameshifting
SH3-binding
Serine protease
Thiol protease
Transcription regulation
Transmembrane helix
Ubl conjugation
Viral RNA replication
Viral attachment to host adhesion receptor
Viral attachment to host entry receptor
Viral envelope protein
Viral ion channel
Viral nucleoprotein
Zinc

Gene Ontology (GO)

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GO Term
endoplasmic reticulum-Golgi intermediate compartment membrane
ribonucleoprotein complex
host cell mitochondrial membrane
viral envelope
host cell plasma membrane
host cell nucleus
host cell endoplasmic reticulum membrane
host cell perinuclear region of cytoplasm
virion membrane
host cell lipid droplet

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

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GO Term
proteolysis
monoatomic ion transmembrane transport
negative regulation of protein secretion
disruption by virus of host TRAF-mediated signal transduction
suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
adhesion receptor-mediated virion attachment to host cell
negative regulation of transcription by RNA polymerase II
virus-mediated perturbation of host defense response
induction by virus of host autophagy
fusion of virus membrane with host endosome membrane

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GO Term
serine-type endopeptidase activity
zinc ion binding
DNA clamp loader activity
RNA binding
RNA helicase activity
RNA-dependent RNA polymerase activity
cysteine-type endopeptidase activity
structural molecule activity
ATP binding
channel activity

Annotation information from UniProt.

Sequence

MSTNPKPQRKKPNVTPTVAHRTSSSRVAVRSLVEFTCCRAGALDWVCARRGRLPSGRNLEVDVSLSPRHVGPRAGPGLSPGTLGPSMAMRVAGGRDGSCLPVALGLAGAPQTPGVGRAIWVRSSIPLRAASPTSWGTYRSSAPLLEALPGPWRMASGFWKTA

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 18 in total

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Position	Description	PubMed ID	GlyTouCan ID	Source
110				GlyGen
196	N-linked (GlcNAc...) asparagine; by host	10211957		UniProt GlyGen
209	N-linked (GlcNAc...) asparagine; by host	10211957		UniProt GlyGen
234	N-linked (GlcNAc...) asparagine; by host	10211957		UniProt GlyGen
243				GlyGen
245				GlyGen
305	N-linked (GlcNAc...) asparagine; by host	10211957		UniProt GlyGen
417	N-linked (GlcNAc...) (high mannose) asparagine; by host	18187336	G80920RR G62765YT G31852PQ G41247ZX G02815KT G92050GC G28681TP	UniProt GlyGen
423	N-linked (GlcNAc...) (high mannose) asparagine; by host	18187336	G41247ZX G80475RE G02815KT G57317CE G92050GC G28681TP	UniProt GlyGen
430	N-linked (GlcNAc...) (high mannose) asparagine; by host	18187336 24288331	G25987BV G80475RE G20956ZV	UniProt GlyGen