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Cyclic nucleotide-gated channel alpha-1

Summary

UniProt ID: P29973
Gene Symbol: CNCG CNCG1 CNGA1
Gene ID: 1259
Organism: Homo sapiens (human)

External Links

PubChem: P29973
The Human Metabolome Database: HMDBP01124
Re-Glyco: P29973

Annotation

Keyword: 3D-structure Calcium channel Cell membrane Coiled coil Disease variant Glycoprotein Ligand-gated ion channel Proteomics identification Reference proteome Retinitis pigmentosa Sodium channel Transmembrane helix Vision cAMP-binding cGMP-binding

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
sodium ion transport	ISS	GO_REF
calcium ion transport	ISS	GO_REF
visual perception	TAS	PMID
visual perception	IMP	PMID
sensory perception of chemical stimulus	IBA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of chemical stimulus

sensory perception of light stimulus [inference]

visual perception

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

monoatomic cation transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
plasma membrane	TAS	PMID Reactome Reactome Reactome Reactome
plasma membrane	IDA	GO_REF
plasma membrane	IBA	GO_REF
plasma membrane	IEA	GO_REF
intracellular cyclic nucleotide activated cation channel complex	ISS	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

intracellular cyclic nucleotide activated cation channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

intracellular cyclic nucleotide activated cation channel complex

cellular anatomical structure [inference]

photoreceptor outer segment [inference]

rod photoreceptor outer segment

membrane [inference]

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

ciliary membrane [inference]

photoreceptor outer segment membrane

plasma membrane region [inference]

cell projection membrane [inference]

ciliary membrane [inference]

photoreceptor outer segment membrane

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	Reference
intracellularly cAMP-activated cation channel activity	IDA	PMID
intracellularly cAMP-activated cation channel activity	IBA	GO_REF
intracellularly cGMP-activated cation channel activity	ISS	GO_REF
intracellularly cGMP-activated cation channel activity	IDA	PMID
intracellularly cGMP-activated cation channel activity	IBA	GO_REF

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

intracellularly cyclic nucleotide-activated monoatomic cation channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

intracellularly ligand-gated monoatomic ion channel activity [inference]

intracellularly cyclic nucleotide-activated monoatomic cation channel activity [inference]

cyclic nucleotide-activated monoatomic ion channel activity [inference]

intracellularly cyclic nucleotide-activated monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

intracellularly cyclic nucleotide-activated monoatomic cation channel activity [inference]

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

intracellularly cyclic nucleotide-activated monoatomic cation channel activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity

calcium ion transmembrane transporter activity [inference]

calcium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

intracellularly cyclic nucleotide-activated monoatomic cation channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

intracellularly ligand-gated monoatomic ion channel activity [inference]

intracellularly cyclic nucleotide-activated monoatomic cation channel activity [inference]

cyclic nucleotide-activated monoatomic ion channel activity [inference]

intracellularly cyclic nucleotide-activated monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

intracellularly cyclic nucleotide-activated monoatomic cation channel activity [inference]

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

intracellularly ligand-gated monoatomic ion channel activity [inference]

intracellularly cyclic nucleotide-activated monoatomic cation channel activity [inference]

cyclic nucleotide-activated monoatomic ion channel activity [inference]

intracellularly cyclic nucleotide-activated monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

intracellularly cyclic nucleotide-activated monoatomic cation channel activity [inference]

binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

cGMP binding

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

guanyl ribonucleotide binding [inference]

cGMP binding

cyclic nucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

guanyl ribonucleotide binding [inference]

cGMP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

guanyl ribonucleotide binding [inference]

cGMP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

cGMP binding

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

guanyl ribonucleotide binding [inference]

cGMP binding

cyclic nucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

cAMP binding

guanyl ribonucleotide binding [inference]

cGMP binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MKNNIINTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSEESENENPHARGSFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLTKVEKFLKPLIDTEFSSIEGPGAESGPIDST

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
325	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Activation of the phototransduction cascade	Homo sapiens
Inactivation, recovery and regulation of the phototransduction cascade	Homo sapiens

Disease

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:10584	retinitis pigmentosa	Alliance of Genome Resources
DOID:0110377	retinitis pigmentosa 49	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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External Links

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International Collaboration

Acknowledgements