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Activation of the phototransduction cascade

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-2485179

PubChem

R-HSA-2485179

Description

The photoreceptor cascade starts with light isomerization of 11-cis-retinal (11cRAL) of rhodopsin (RHO) to all-trans-retinal (atRAL), inducing a conformational change in RHO to the active, metarhodopsin II (MII) state. MII activates the G protein transducin (Gt) that in turn activates phosphodiesterase 6 (PDE6). Consequently, there is a fall in the intracellular concentration of cGMP that closes cGMP-dependent cation channels (CNG channels) and hyperpolarizes the rod. This has the effect of reducing or stopping glutamate release from synaptic vesicles thus signalling to the surrounding cells how many photons were absorbed (Burns & Pugh 2010, Korenbrot 2012, Pugh & Lamb 1993).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 6** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O60721	Sodium/potassium/calcium exchanger 1	KIAA0702 NCKX1 SLC24A1	view
P08100	Rhodopsin	OPN2 RHO	view
P29973	Cyclic nucleotide-gated channel alpha-1	CNCG CNCG1 CNGA1	view
P35913	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	PDE6B PDEB	view
P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	GNB1	view
Q14028	Cyclic nucleotide-gated channel beta-1	CNCG2 CNCG3L CNCG4 CNGB1 RCNC2	view

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