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MIRAGE
RAC-alpha serine/threonine-protein kinase
Summary
- UniProt ID
- P31749
- Gene Symbol
- AKT1 PKB RAC
- Gene ID
- 207
- Organism
- Homo sapiens (human)
Annotation
- Keyword
- 3D-structure ATP-binding Acetylation Alternative splicing Apoptosis Cell membrane Cytoplasm Developmental protein Disease variant Disulfide bond Glucose metabolism Glycogen biosynthesis Glycogen metabolism Glycoprotein Isopeptide bond Mitochondrion Neurogenesis Nucleus Phosphoprotein Proteomics identification Proto-oncogene Reference proteome Serine/threonine-protein kinase Sugar transport Translation regulation Ubl conjugation
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| osteoblast differentiation | ||
| maternal placenta development |
|
|
| positive regulation of endothelial cell proliferation | ||
| cell migration involved in sprouting angiogenesis | ||
| complement receptor mediated signaling pathway |
GO Hierarchy
- regulation of myelination
biological process
cellular process [inference]
response to stimulus [inference]
response to stress [inference]
response to endogenous stimulus [inference]
response to chemical [inference]
cellular response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of signaling [inference]
regulation of signal transduction [inference]
negative regulation of signal transduction [inference]
regulation of intracellular signal transduction [inference]
regulation of apoptotic signaling pathway [inference]
negative regulation of signaling [inference]
regulation of localization [inference]
regulation of protein localization [inference]
regulation of transport [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
positive regulation of cellular process [inference]
positive regulation of protein localization [inference]
negative regulation of biological process [inference]
negative regulation of signaling [inference]
negative regulation of cellular process [inference]
negative regulation of metabolic process [inference]
negative regulation of cell communication [inference]
negative regulation of programmed cell death [inference]
negative regulation of response to stimulus [inference]
regulation of response to stimulus [inference]
regulation of signal transduction [inference]
negative regulation of signal transduction [inference]
regulation of intracellular signal transduction [inference]
regulation of apoptotic signaling pathway [inference]
negative regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
signal transduction
regulation of cell communication [inference]
regulation of signal transduction [inference]
negative regulation of signal transduction [inference]
regulation of intracellular signal transduction [inference]
regulation of apoptotic signaling pathway [inference]
negative regulation of cell communication [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of catabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of lipid metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of transmembrane transport [inference]
regulation of programmed cell death [inference]
regulation of apoptotic process
negative regulation of apoptotic process
regulation of neuron apoptotic process [inference]
regulation of apoptotic signaling pathway [inference]
negative regulation of programmed cell death [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
negative regulation of metabolic process [inference]
negative regulation of cell communication [inference]
negative regulation of programmed cell death [inference]
regulation of cellular component organization [inference]
regulation of cell cycle [inference]
| GO Term | Evidence Code | Reference |
|---|---|---|
| nucleus | ||
| nucleus | ||
| nucleus | ||
| nucleoplasm | ||
| nucleoplasm |
| GO Term | Evidence Code | Reference |
|---|---|---|
| protein kinase activity | ||
| protein kinase activity | ||
| protein kinase activity | ||
| protein serine/threonine kinase activity | ||
| protein serine/threonine kinase activity |
GO Hierarchy
Sequence
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 126 |
|
|||
| 129 |
|
|||
| 305 |
|
|||
| 308 |
|
|||
| 312 |
|
|||
| 473 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| AKT phosphorylates targets in the cytosol | Homo sapiens |
| AKT phosphorylates targets in the nucleus | Homo sapiens |
| AKT-mediated inactivation of FOXO1A | Homo sapiens |
| Activation of BAD and translocation to mitochondria | Homo sapiens |
| Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA | Homo sapiens |
| CD28 dependent PI3K/Akt signaling | Homo sapiens |
| Co-inhibition by CTLA4 | Homo sapiens |
| Constitutive Signaling by AKT1 E17K in Cancer | Homo sapiens |
| Cyclin A:Cdk2-associated events at S phase entry | Homo sapiens |
| Cyclin E associated events during G1/S transition | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:7575 | pancreatic intraductal papillary-mucinous neoplasm | |
| DOID:2526 | prostate adenocarcinoma | |
| DOID:14330 | Parkinson's disease | |
| DOID:13482 | Proteus syndrome | |
| DOID:3312 | bipolar disorder | |
| DOID:219 | colon cancer | |
| DOID:2394 | ovarian cancer | |
| DOID:10283 | prostate cancer | |
| DOID:3008 | invasive ductal carcinoma | |
| DOID:1793 | pancreatic cancer |
