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AKT-mediated inactivation of FOXO1A

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-211163

PubChem

R-HSA-211163

Description

The unphosphorylated form of FOXO1A shuttles between the nucleus and cytoplasm, maintaining a substantial concentration of this protein in the nucleoplasm, where it functions as a transcription factor. Phosphorylation of the protein, catalyzed by activated AKT, causes its exclusion from the nucleus (Zhang et al. 2002).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 4** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P31749	RAC-alpha serine/threonine-protein kinase	AKT1 PKB RAC	view
P31751	RAC-beta serine/threonine-protein kinase	AKT2	view
Q12778	Forkhead box protein O1	FKHR FOXO1 FOXO1A	view
Q9Y243	RAC-gamma serine/threonine-protein kinase	AKT3 PKBG	view

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