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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Long-chain-fatty-acid--CoA ligase 1
Summary
- UniProt ID
- P33121
- Gene Symbol
-
- ACSL1
- FACL1
- FACL2
- LACS
- LACS1
- LACS2
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P33121
- PubChem
- P33121
- SwissLipids
- The Human Metabolome Database
- HMDBP00577
- The O-GlcNAc Database
- P33121
- RaftProt
- P33121
Annotation
- Keyword
-
- ATP-binding
- Acetylation
- Alternative splicing
- Direct protein sequencing
- Fatty acid metabolism
- Glycoprotein
- Ligase
- Magnesium
- Microsome
- Mitochondrion outer membrane
- Nitration
- Peroxisome
- Phosphoprotein
- Reference proteome
- Signal-anchor
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| membrane |
| mitochondrion |
| endoplasmic reticulum |
| endoplasmic reticulum membrane |
| mitochondrial outer membrane |
| peroxisomal membrane |
Sequence
MQAHELFRYFRMPELVDFRQYVRTLPTNTLMGFGAFAALTTFWYATRPKPLKPPCDLSMQSVEVAGSGGARRSALLDSDEPLVYFYDDVTTLYEGFQRGIQVSNNGPCLGSRKPDQPYEWLSYKQVAELSECIGSALIQKGFKTAPDQFIGIFAQNRPEWVIIEQGCFAYSMVIVPLYDTLGNEAITYIVNKAELSLVFVDKPEKAKLLLEGVENKLIPGLKIIVVMDAYGSELVERGQRCGVEVTSMKAMEDLGRANRRKPKPPAPEDLAVICFTSGTTGNPKGAMVTHRNIVSDCSAFVKATENTVNPCPDDTLISFLPLAHMFERVVECVMLCHGAKIGFFQGDIRLLMDDLKVLQPTVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAALGCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGDIGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDVKKAILEDMVRLGKDSGLKPFEQVKGITLHPELFSIDNGLLTPTMKAKRPELRNYFRSQIDDLYSTIKV
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 135 | O-linked (GlcNAc) serine |
|
||
| 246 |
|
|||
| 247 |
|
|||
| 382 |
|
G49108TO
G83460ZZ
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Linoleic acid (LA) metabolism | Homo sapiens |
| PPARA activates gene expression | Homo sapiens |
| Synthesis of very long-chain fatty acyl-CoAs | Homo sapiens |
| alpha-linolenic acid (ALA) metabolism | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110759 | type 1 diabetes mellitus 22 | |
| DOID:0040085 | bacterial sepsis | |
| DOID:0050387 | nonpapillary renal cell carcinoma | |
| DOID:0050589 | inflammatory bowel disease | |
| DOID:0050700 | cardiomyopathy | |
| DOID:0080199 | colorectal carcinoma | |
| DOID:0110741 | type 1 diabetes mellitus 2 | |
| DOID:0110742 | type 1 diabetes mellitus 3 | |
| DOID:0110743 | type 1 diabetes mellitus 4 | |
| DOID:0110744 | type 1 diabetes mellitus 5 |
