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Linoleic acid (LA) metabolism

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-2046105

PubChem

R-HSA-2046105

Description

Linoleic acid (LA, 18:2(n-6)) is an omega-6 fatty acid obtained through diet, mainly from vegetable oils. Omega-6 fatty acids helps stimulate skin and hair growth, maintain bone health, regulate metabolism, and maintain the reproductive system. All the desaturation and elongation steps occur in the endoplasmic reticulum (ER) except for the final step which requires translocation to peroxisomes for partial beta-oxidation. The linoleic acid pathway involves the following steps: 18:2(n-6)-->18:3(n-6)--> 20:3(n-6)-->20:4(n-6)-->22:4(n-6)-->24:4(n-6)-->24:5(n-6)-->22:5(n-6). Two desaturation enzymes are involved in this process: delta-6 desaturase which converts 18:2(n-6) to 18:3 (n-6) and 24:4(n-6) to 24:5(n-6) respectively, and delta-5 desaturase which converts 20:3(n-6) to 20:4(n-6). (Sprecher 2002).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 4** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O60427	Acyl-CoA (8-3)-desaturase	FADS1 FADSD5	view
P33121	Long-chain-fatty-acid--CoA ligase 1	ACSL1 FACL1 FACL2 LACS LACS1 LACS2	view
P33897	ATP-binding cassette sub-family D member 1	ABCD1 ALD	view
Q9HB03	Very long chain fatty acid elongase 3	CIG30 ELOVL3	view

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