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MIRAGE
T-lymphocyte activation antigen CD80
Summary
- UniProt ID
- P33681
- Gene Symbol
- CD80 CD28LG CD28LG1 LAB7
- Gene ID
- 941
- Organism
- Homo sapiens (human)
Annotation
- Keyword
- 3D-structure Alternative splicing Cell membrane Direct protein sequencing Disulfide bond Glycoprotein Host cell receptor for virus entry Host-virus interaction Immunoglobulin domain Palmitate Phosphoprotein Proteomics identification Reference proteome Signal Transmembrane helix
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| negative regulation of T cell mediated immunity | ||
| immune response | ||
| cell surface receptor signaling pathway | ||
| positive regulation of signal transduction | ||
| T cell costimulation |
GO Hierarchy
biological process
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
positive regulation of immune system process [inference]
regulation of leukocyte activation [inference]
regulation of immune response [inference]
regulation of hemopoiesis [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of cellular process [inference]
positive regulation of developmental process [inference]
positive regulation of multicellular organismal process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cell differentiation [inference]
positive regulation of developmental process [inference]
regulation of multicellular organismal development [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of cell adhesion [inference]
regulation of cell population proliferation [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
positive regulation of cell activation [inference]
regulation of multicellular organismal process [inference]
regulation of cytokine production [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
positive regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
regulation of multicellular organismal development [inference]
| GO Term | Evidence Code | Reference |
|---|---|---|
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane |
| GO Term | Evidence Code | Reference |
|---|---|---|
| virus receptor activity |
|
|
| coreceptor activity | ||
| coreceptor activity | ||
| receptor ligand activity |
GO Hierarchy
Sequence
MGHTRRQGTSPSKCPYLNFFQLLVLAGLSHFCSGVIHVTKEVKEVATLSCGHNVSVEELAQTRIYWQKEKKMVLTMMSGDMNIWPEYKNRTIFDITNNLSIVILALRPSDEGTYECVVLKYEKDAFKREHLAEVTLSVKADFPTPSISDFEIPTSNIRRIICSTSGGFPEPHLSWLENGEELNAINTTVSQDPETELYAVSSKLDFNMTTNHSFMCLIKYGHLRVNQTFNWNTTKQEHFPDNLLPSWAITLISVNGIFVICCLTYCFAPRCRERRRNERLRRESVRPV
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 53 |
|
|
||
| 89 |
|
|
||
| 98 |
|
|
||
| 144 |
|
|
||
| 186 |
|
|
||
| 207 |
|
|||
| 211 |
|
|
||
| 226 |
|
|
||
| 232 |
|
|
G80920RR
G02886BB
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| CD28 co-stimulation | Homo sapiens |
| CD28 dependent PI3K/Akt signaling | Homo sapiens |
| CD28 dependent Vav1 pathway | Homo sapiens |
| Co-inhibition by CTLA4 | Homo sapiens |
| Constitutive Signaling by Aberrant PI3K in Cancer | Homo sapiens |
| Interleukin-10 signaling | Homo sapiens |
| PI3K/AKT Signaling | Homo sapiens |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:9744 | type 1 diabetes mellitus |
