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UDP-glucuronosyltransferase 1A3
Summary
- UniProt ID
- P35503
- Gene Symbol
-
- UGT1A3
- GNT1
- UGT1
- Organism
- Homo sapiens (human)
External Links
- GlyConnect
- GlyGen
- P35503
- PubChem
- P35503
- SwissLipids
- The Human Metabolome Database
- HMDBP00486
Annotation
- Keyword
-
- Alternative splicing
- Endoplasmic reticulum
- Glycoprotein
- Glycosyltransferase
- Lipid metabolism
- Reference proteome
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| negative regulation of cellular glucuronidation |
| GO Term |
|---|
| endoplasmic reticulum |
| endoplasmic reticulum membrane |
| GO Term |
|---|
| enzyme binding |
| protein homodimerization activity |
| protein heterodimerization activity |
| retinoic acid binding |
| glucuronosyltransferase activity |
Sequence
MATGLQVPLPWLATGLLLLLSVQPWAESGKVLVVPIDGSHWLSMREVLRELHARGHQAVVLTPEVNMHIKEENFFTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRSMAMLNNMSLVYHRSCVELLHNEALIRHLNATSFDVVLTDPVNLCAAVLAKYLSIPTVFFLRNIPCDLDFKGTQCPNPSSYIPRLLTTNSDHMTFMQRVKNMLYPLALSYICHAFSAPYASLASELFQREVSVVDILSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANRKPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 119 | N-linked (GlcNAc...) asparagine |
|
||
| 142 | N-linked (GlcNAc...) asparagine | |||
| 296 | N-linked (GlcNAc...) asparagine |
|
||
| 348 | N-linked (GlcNAc...) asparagine |
|
G72747WU
G62765YT
G60834IK
G31986NC
G87389XI
G23505EP
G76295SF
G46691LC
G04657PL
G27058EU
G24528MX
G83460ZZ
G07755XJ
G92406TI
G41840AI
G80920RR
G01485JJ
G77547TA
G59924QI
G88891KO
G95177YH
G18647XP
G85269DF
G31852PQ
G90575OW
G23719VF
G39446WN
G11314AS
G39188ZX
G41247ZX
G50282JC
G35029YA
G57776ZU
G36379GD
G02815KT
G84349RE
G57317CE
G92050GC
G92275SC
G14669DU
G28681TP
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Aspirin ADME | Homo sapiens |
| Atorvastatin ADME | Homo sapiens |
| Glucuronidation | Homo sapiens |
| LXRs regulate gene expression to control bile acid homeostasis | Homo sapiens |
| Prednisone ADME | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:2047 | hepatitis D | |
| DOID:0050424 | familial adenomatous polyposis | |
| DOID:0050590 | severe congenital neutropenia | |
| DOID:0060262 | gallbladder disease | |
| DOID:0080409 | familial adenomatous polyposis 1 | |
| DOID:0080525 | differentiated thyroid gland carcinoma | |
| DOID:0110845 | xeroderma pigmentosum group D | |
| DOID:10211 | cholelithiasis | |
| DOID:10241 | thalassemia | |
| DOID:10283 | prostate cancer |
