Receptor-type tyrosine-protein kinase FLT3

Summary
UniProt ID
P36888
Gene Symbol
  • FLT3
  • CD135
  • FLK2
  • STK1
Organism
Homo sapiens (human)
External Links
GlyGen
P36888
PubChem
P36888
The Human Metabolome Database
HMDBP01189
Annotation
Keyword
  • 3D-structure
  • ATP-binding
  • Alternative splicing
  • Disease variant
  • Disulfide bond
  • Endoplasmic reticulum
  • Glycoprotein
  • Host-virus interaction
  • Immunoglobulin domain
  • Phosphoprotein
  • Proto-oncogene
  • Receptor
  • Reference proteome
  • Signal
  • Transmembrane helix
  • Tyrosine-protein kinase
  • Ubl conjugation
Gene Ontology (GO)
Sequence
MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS
Glycosylation Sites
Displaying all 10 entries
Position Description PubMed ID GlyTouCan ID Source
43 N-linked (GlcNAc...) asparagine
100 N-linked (GlcNAc...) asparagine
151 N-linked (GlcNAc...) asparagine
306 N-linked (GlcNAc...) asparagine
323 N-linked (GlcNAc...) asparagine
351 N-linked (GlcNAc...) asparagine
354 N-linked (GlcNAc...) asparagine
473
502
541 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying entries 1 - 10 of 27 in total
Pathway Name Organism
Constitutive Signaling by Aberrant PI3K in Cancer Homo sapiens
FLT3 Signaling Homo sapiens
FLT3 mutants bind TKIs Homo sapiens
FLT3 signaling by CBL mutants Homo sapiens
FLT3 signaling through SRC family kinases Homo sapiens
KW2449-resistant FLT3 mutants Homo sapiens
Negative regulation of FLT3 Homo sapiens
PI3K Cascade Homo sapiens
PI3K/AKT Signaling Homo sapiens
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Homo sapiens

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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024