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Metabotropic glutamate receptor 5

Summary

UniProt ID

P41594

Gene Symbol

GPRC1E
GRM5
MGLUR5

Gene ID

2915

Organism

Homo sapiens (human)

External Links

GlyGen: P41594
PubChem: P41594
The Human Metabolome Database: HMDBP02180
The O-GlcNAc Database: P41594
O-GlcNAcAtlas: P41594
Re-Glyco: P41594

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Methylation
Phosphoprotein
Reference proteome
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying **all 10** entries
GO Term
Schaffer collateral - CA1 synapse
glutamatergic synapse
cytoplasm
plasma membrane
dendrite
neuronal cell body
dendritic spine
dendritic shaft
astrocyte projection
postsynaptic density membrane

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 16 in total

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GO Term
regulation of synaptic transmission, glutamatergic
learning
positive regulation of MAPK cascade
synapse organization
positive regulation of calcium-mediated signaling
cellular response to amyloid-beta
desensitization of G protein-coupled receptor signaling pathway
phospholipase C-activating G protein-coupled glutamate receptor signaling pathway
G protein-coupled glutamate receptor signaling pathway
positive regulation of long-term neuronal synaptic plasticity

Displaying **all 9** entries
GO Term
G protein-coupled receptor activity
protein tyrosine kinase activator activity
glutamate receptor activity
identical protein binding
protein tyrosine kinase binding
adenylate cyclase inhibiting G protein-coupled glutamate receptor activity
A2A adenosine receptor binding
neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential

Annotation information from UniProt.

Sequence

MVLLLILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTLKTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMDDDEVWSKKSNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTSTVVRMHVGDGKSSSAASRSSSLVNLWKRRGSSGETLRYKDRRLAQHKSEIECFTPKGSMGNGGRATMSSSNGKSVTWAQNEKSSRGQHLWQRLSIHINKKENPNQTAVIKPFPKSTESRGLGAGAGAGGSAGGVGATGGAGCAGAGPGGPESPDAGPKALYDVAEAEEHFPAPARPRSPSPISTLSHRAGSASRTDDDVPSLHSEPVARSSSSQGSLMEQISSVVTRFTANISELNSMMLSTAAPSPGVGAPLCSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQPAAGAQAAGDAARESPAAGPEAAAAKPDLEELVALTPPSPFRDSVDSGSTTPNSPVSESALCIPSSPKYDTLIIRDYTQSSSSL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 9** entries
Position	Description	GlyTouCan ID	Source
88	N-linked (GlcNAc...) asparagine		UniProt GlyGen
210	N-linked (GlcNAc...) asparagine		UniProt GlyGen
378	N-linked (GlcNAc...) asparagine		UniProt GlyGen
382	N-linked (GlcNAc...) asparagine		UniProt GlyGen
445	N-linked (GlcNAc...) asparagine		UniProt GlyGen
734	N-linked (GlcNAc...) asparagine		UniProt GlyGen
854		G49108TO	GlyGen
1050		G49108TO	GlyGen The O-GlcNAc Database
1051		G49108TO	GlyGen The O-GlcNAc Database