Submissions
GlyTouCan
Glycan Structure Repository
GlyComb
Glycoconjugate Repository
GlycoPOST
Glycomics MS raw data Repository
UniCarb-DR
Glycomics MS Repository for glycan annotations from GlycoWorkbench
LM-GlycoRepo
Repository for lectin-assisted multimodality data
All Resources
Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / OrganismsTools
SugarDrawer
GlycanBuilder
Glycan Converters
GlycoMaple
GlycomeAtlas
LM-GlycomeAtlas
GALAXY
MCAW
GlycoSim
GRable
Guidelines
MIRAGE
T-lymphocyte activation antigen CD86
Summary
- UniProt ID
- P42081
- Gene Symbol
- CD28LG2 CD86
- Gene ID
- 942
- Organism
- Homo sapiens (human)
Annotation
- Keyword
- 3D-structure Adaptive immunity Alternative splicing Cell membrane Disulfide bond Glycoprotein Host cell receptor for virus entry Host-virus interaction Immunoglobulin domain Proteomics identification Reference proteome Signal Transmembrane helix Ubl conjugation
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| adaptive immune response |
|
|
| positive regulation of immunoglobulin production | ||
| immune response | ||
| immune response | ||
| cell surface receptor signaling pathway |
GO Hierarchy
biological process
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
positive regulation of immune system process [inference]
regulation of leukocyte activation [inference]
regulation of immune effector process [inference]
regulation of immune response [inference]
regulation of hemopoiesis [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of cellular process [inference]
positive regulation of response to stimulus [inference]
positive regulation of developmental process [inference]
positive regulation of multicellular organismal process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cell differentiation [inference]
positive regulation of developmental process [inference]
regulation of multicellular organismal development [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of cell adhesion [inference]
regulation of cell population proliferation [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
positive regulation of cell activation [inference]
regulation of multicellular organismal process [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
positive regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
regulation of multicellular organismal development [inference]
| GO Term | Evidence Code | Reference |
|---|---|---|
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane |
GO Hierarchy
| GO Term | Evidence Code | Reference |
|---|---|---|
| virus receptor activity |
|
|
| coreceptor activity | ||
| signaling receptor activity | ||
| receptor ligand activity |
GO Hierarchy
Sequence
MDPQCTMGLSNILFVMAFLLSGAAPLKIQAYFNETADLPCQFANSQNQSLSELVVFWQDQENLVLNEVYLGKEKFDSVHSKYMGRTSFDSDSWTLRLHNLQIKDKGLYQCIIHHKKPTGMIRIHQMNSELSVLANFSQPEIVPISNITENVYINLTCSSIHGYPEPKKMSVLLRTKNSTIEYDGVMQKSQDNVTELYDVSISLSVSFPDVTSNMTIFCILETDKTRLLSSPFSIELEDPQPPPDHIPWITAVLPTVIICVMVFCLILWKWKKKKRPRNSYKCGTNTMEREESEQTKKREKIHIPERSDEAQRVFKSSKTSSCDKSDTCF
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 33 |
|
|
||
| 47 |
|
|
||
| 135 |
|
|
||
| 146 |
|
|
||
| 154 |
|
|
||
| 177 |
|
|
||
| 192 |
|
|
||
| 213 |
|
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| CD28 co-stimulation | Homo sapiens |
| CD28 dependent PI3K/Akt signaling | Homo sapiens |
| CD28 dependent Vav1 pathway | Homo sapiens |
| Co-inhibition by CTLA4 | Homo sapiens |
| Constitutive Signaling by Aberrant PI3K in Cancer | Homo sapiens |
| Interleukin-10 signaling | Homo sapiens |
| PI3K/AKT Signaling | Homo sapiens |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:11123 | IgA vasculitis | |
| DOID:1040 | chronic lymphocytic leukemia | |
| DOID:9744 | type 1 diabetes mellitus | |
| DOID:2377 | multiple sclerosis | |
| DOID:418 | systemic scleroderma | |
| DOID:2841 | asthma | |
| DOID:8924 | autoimmune thrombocytopenic purpura | |
| DOID:3083 | chronic obstructive pulmonary disease |
