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Lysosomal Pro-X carboxypeptidase

Summary

UniProt ID: P42785
Gene Symbol: PRCP PCP
Gene ID: 5547
Organism: Homo sapiens (human)

External Links

GlyConnect

Lysosomal Pro-X carboxypeptidase

GlyGen

P42785

PubChem

P42785

The O-GlcNAc Database

P42785

O-GlcNAcAtlas

P42785

Re-Glyco

P42785

Annotation

Keyword: 3D-structure Alternative splicing Carboxypeptidase Direct protein sequencing Disulfide bond Glycoprotein Lysosome Proteomics identification Reference proteome Signal Zymogen

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	Reference
angiotensin maturation	IEA	GO_REF
regulation of thyroid hormone receptor signaling pathway
plasma kallikrein-kinin cascade
negative regulation of systemic arterial blood pressure	IBA	GO_REF
glucose homeostasis

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

hormone metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein activation cascade [inference]

kinin cascade [inference]

plasma kallikrein-kinin cascade

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein activation cascade [inference]

kinin cascade [inference]

plasma kallikrein-kinin cascade

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

energy homeostasis

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis [inference]

angiogenesis involved in wound healing

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

energy homeostasis

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response [inference]

acute inflammatory response [inference]

kinin cascade [inference]

plasma kallikrein-kinin cascade

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of thyroid hormone receptor signaling pathway

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of endothelial cell migration [inference]

regulation of blood vessel endothelial cell migration

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of thyroid hormone receptor signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of thyroid hormone receptor signaling pathway

regulation of metabolic process [inference]

regulation of reactive oxygen species metabolic process

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of endothelial cell migration [inference]

regulation of blood vessel endothelial cell migration

regulation of biological quality [inference]

regulation of blood pressure [inference]

negative regulation of blood pressure [inference]

negative regulation of systemic arterial blood pressure

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

Displaying **all 5** entries
GO Term	Evidence Code	Reference
plasma membrane	TAS	Reactome Reactome Reactome
azurophil granule membrane	TAS	Reactome
basal part of cell	IEA	GO_REF
extracellular exosome	HDA	PMID PMID
ficolin-1-rich granule membrane	TAS	Reactome

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane [inference]

azurophil granule membrane

secretory granule membrane [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

basal part of cell

Displaying **all 4** entries
GO Term	Evidence Code	Reference
metallocarboxypeptidase activity	IEA	GO_REF
serine-type carboxypeptidase activity	TAS	PMID
serine-type carboxypeptidase activity	IEA	GO_REF
dipeptidyl-peptidase activity

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

serine-type peptidase activity [inference]

serine-type exopeptidase activity [inference]

serine-type carboxypeptidase activity

metallopeptidase activity [inference]

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity [inference]

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

dipeptidyl-peptidase activity

serine-type exopeptidase activity [inference]

serine-type carboxypeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type exopeptidase activity [inference]

serine-type carboxypeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

serine-type peptidase activity [inference]

serine-type exopeptidase activity [inference]

serine-type carboxypeptidase activity

metallopeptidase activity [inference]

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity [inference]

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

dipeptidyl-peptidase activity

serine-type exopeptidase activity [inference]

serine-type carboxypeptidase activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHFGFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRSWDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWSYQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 13 in total

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Position	Description	PubMed ID	GlyTouCan ID	Source
28		23584533	G57321FI	GlyGen
39		23584533 25813380 30459171	G43417UB G57321FI	GlyGen
47	N-linked (GlcNAc...) asparagine	23090970 24190977 29741879 37074911	G64751KD G69521XL G34989PA G45395BF G58954YZ G00912UN G83646BJ G27058EU G83460ZZ G23984SE G41071NU G49018RC G01650EU G80920RR G42124LM G02886BB G64409MC G62765YT G47950XN G62894KT G11870QZ G47644PP G72790NZ G95177YH G28541PG G95865ZB G05724UK G31852PQ G90575OW G23719VF G39188ZX G41247ZX G50282JC G02815KT G92050GC G74724QE G92275SC G28681TP	UniProt GlyGen GlyConnect
49		34019948 35289036 38665916 39531497	G49108TO	GlyGen The O-GlcNAc Database
63		24190977		GlyGen
101	N-linked (GlcNAc...) asparagine	20540760		UniProt GlyGen
317	N-linked (GlcNAc...) asparagine	19159218 20540760 37074911	G67164EE G95046LV G56518TU G69521XL G99668VU G94470IW G45395BF G59324HL G07246CJ G56307ZW G49906RN G36442WJ G15664MX G49018RC G72747WU G02886BB G90659AW G10486CT G28541PG G18647XP G39446WN G57776ZU G36379GD G02815KT G57317CE G54010QB G84225JN	UniProt GlyGen
319		34019948 35289036 38665916 39531497	G49108TO	The O-GlcNAc Database
336	N-linked (GlcNAc...) asparagine	20540760		UniProt GlyGen
345	N-linked (GlcNAc...) asparagine	20540760		UniProt GlyGen