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Prestin

Summary

UniProt ID: P58743
Gene Symbol: SLC26A5 PRES
Gene ID: 375611
Organism: Homo sapiens (human)

External Links

GlyGen: P58743
PubChem: P58743
The Human Metabolome Database: HMDBP07429
Re-Glyco: P58743

Annotation

Keyword: 3D-structure Alternative splicing Cell membrane Cell shape Glycoprotein Hearing Motor protein Non-syndromic deafness Proteomics identification Reference proteome Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	Reference
response to ischemia	IEA	GO_REF
chloride transport	ISS	GO_REF
chloride transport	IEA	GO_REF
sensory perception of sound	IMP	PMID
sensory perception of sound	IBA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

fructose transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

sulfate transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

positive regulation of cell size

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

developmental process [inference]

anatomical structure development [inference]

animal gross anatomical part developmental process [inference]

cochlea development

response to stimulus [inference]

response to stress [inference]

response to ischemia

response to external stimulus [inference]

response to mechanical stimulus [inference]

response to auditory stimulus

response to abiotic stimulus [inference]

response to mechanical stimulus [inference]

response to auditory stimulus

response to endogenous stimulus [inference]

response to hormone [inference]

response to thyroid hormone

response to chemical [inference]

response to xenobiotic stimulus

response to hormone [inference]

response to thyroid hormone

response to metal ion [inference]

response to potassium ion

response to oxygen-containing compound [inference]

response to salicylic acid

response to salt

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic anion transport [inference]

chloride transport

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

carbohydrate transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

fructose transmembrane transport

inorganic anion transport [inference]

chloride transport

chloride transmembrane transport

sulfate transmembrane transport

bicarbonate transport

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

oxalate transport

transmembrane transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

fructose transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

sulfate transmembrane transport

sulfur compound transport [inference]

sulfate transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport

regulation of monoatomic ion transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport

negative regulation of monoatomic ion transport [inference]

negative regulation of monoatomic ion transmembrane transport

negative regulation of transport [inference]

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport

negative regulation of monoatomic ion transport [inference]

negative regulation of monoatomic ion transmembrane transport

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility

regulation of cell motility [inference]

positive regulation of cell motility

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility

positive regulation of cellular process [inference]

positive regulation of cell motility

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport

negative regulation of transport [inference]

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport

negative regulation of monoatomic ion transport [inference]

negative regulation of monoatomic ion transmembrane transport

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of cell shape

regulation of cellular process [inference]

regulation of transmembrane transport [inference]

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport

positive regulation of cellular process [inference]

positive regulation of cell motility

negative regulation of cellular process [inference]

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport

regulation of cell motility [inference]

positive regulation of cell motility

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

positive regulation of cell size

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GO Term	Evidence Code	Reference
plasma membrane	IEA	GO_REF
basolateral plasma membrane	ISS	GO_REF
basolateral plasma membrane	IEA	GO_REF
lateral plasma membrane	IDA	PMID PMID
lateral plasma membrane	IEA	GO_REF GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

basolateral plasma membrane

lateral plasma membrane

lateral part of cell [inference]

lateral wall of outer hair cell

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
secondary active sulfate transmembrane transporter activity	IEA	GO_REF
sulfate transmembrane transporter activity	IBA	GO_REF
oxalate transmembrane transporter activity	IBA	GO_REF
spectrin binding	IEA	GO_REF
protein homodimerization activity	IDA	PMID

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride:bicarbonate antiporter activity

bicarbonate:monoatomic anion antiporter activity [inference]

chloride:bicarbonate antiporter activity

bicarbonate transmembrane transporter activity [inference]

bicarbonate:monoatomic anion antiporter activity [inference]

chloride:bicarbonate antiporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

secondary active sulfate transmembrane transporter activity

antiporter activity [inference]

solute:inorganic anion antiporter activity [inference]

chloride:bicarbonate antiporter activity

bicarbonate:monoatomic anion antiporter activity [inference]

chloride:bicarbonate antiporter activity

carboxylic acid transmembrane transporter activity [inference]

dicarboxylic acid transmembrane transporter activity [inference]

oxalate transmembrane transporter activity

sulfur compound transmembrane transporter activity [inference]

sulfate transmembrane transporter activity

secondary active sulfate transmembrane transporter activity

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

spectrin binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

protein-containing complex binding [inference]

spectrin binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQINAPIYYANSDLYSNALKRKTGVNPAVIMGARRKAMRKYAKEVGNANMANATVVKADAEVDGEDATKPEEEDGEVKYPPIVIKSTFPEEMQRFMPPGDNVHTVILDFTQVNFIDSVGVKTLAGIVKEYGDVGIYVYLAGCSAQVVNDLTRNRFFENPALWELLFHSIHDAVLGSQLREALAEQEASAPPSQEDLEPNATPATPEA

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	PubMed ID	Source
163	N-linked (GlcNAc...) asparagine	15140192 19898896	UniProt GlyGen
166	N-linked (GlcNAc...) asparagine	15140192 19898896	UniProt GlyGen
738			GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Sensory processing of sound by outer hair cells of the cochlea	Homo sapiens

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110513	autosomal recessive nonsyndromic deafness 61	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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