C-X-C chemokine receptor type 4

Summary
UniProt ID
P70658
Gene Symbol
Cxcr4 Cmkar4 Lestr Sdf1r
Gene ID
12767
Organism
Mus musculus (house mouse)
PubChem
P70658
The Human Metabolome Database
HMDBP13791
Re-Glyco
P70658
Annotation
Keyword
Alternative splicing Cell junction Cell membrane Disulfide bond Endosome G-protein coupled receptor Isopeptide bond Lysosome Phosphoprotein Proteoglycan Reference proteome Sulfation Transmembrane helix Ubl conjugation
Gene Ontology (GO)
GO Hierarchy
Sequence
MEPISVSIYTSDNYSEEVGSGDYDSNKEPCFRDENVHFNRIFLPTIYFIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAMADWYFGKFLCKAVHIIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKAVYVGVWIPALLLTIPDFIFADVSQGDISQGDDRYICDRLYPDSLWMVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYVGISIDSFILLGVIKQGCDFESIVHKWISITEALAFFHCCLNPILYAFLGAKFKSSAQHALNSMSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
Glycosylation Sites
Displaying all 2 entries
Position Description PubMed ID GlyTouCan ID Source
13
  • N-linked (GlcNAc...) asparagine
20
  • O-linked (Xyl...) (chondroitin sulfate) serine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 3 entries
Pathway Name Organism
Chemokine receptors bind chemokines Mus musculus
G alpha (i) signalling events Mus musculus
Signaling by ROBO receptors Mus musculus
Disease
Displaying all 3 entries
DO ID Disease Name Source
DOID:0060591 WHIM syndrome 1
DOID:6000 congestive heart failure
DOID:0050700 cardiomyopathy

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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 6, 2026