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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Dual specificity mitogen-activated protein kinase kinase 1
Summary
- UniProt ID
- Q02750
- Gene Symbol
-
- MAP2K1
- MEK1
- PRKMK1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Acetylation
- Alternative splicing
- Cardiomyopathy
- Cytoskeleton
- Direct protein sequencing
- Disease variant
- Ectodermal dysplasia
- Intellectual disability
- Membrane
- Nucleus
- Phosphoprotein
- Reference proteome
- Serine/threonine-protein kinase
- Tyrosine-protein kinase
- Gene Ontology (GO)
| GO Term |
|---|
| MAPK cascade |
| insulin-like growth factor receptor signaling pathway |
| regulation of stress-activated MAPK cascade |
| ERBB2-ERBB3 signaling pathway |
| ERK1 and ERK2 cascade |
| positive regulation of ERK1 and ERK2 cascade |
| GO Term |
|---|
| nucleus |
| Golgi apparatus |
| plasma membrane |
| mitochondrion |
| cytosol |
| endoplasmic reticulum |
| centrosome |
| early endosome |
| late endosome |
| focal adhesion |
| GO Term |
|---|
| protein kinase activator activity |
Sequence
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 21 |
|
|||
|
|
G40206WX
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Frs2-mediated activation | Homo sapiens |
| MAP2K and MAPK activation | Homo sapiens |
| MAP3K8 (TPL2)-dependent MAPK1/3 activation | Homo sapiens |
| MAPK3 (ERK1) activation | Homo sapiens |
| Negative feedback regulation of MAPK pathway | Homo sapiens |
| Paradoxical activation of RAF signaling by kinase inactive BRAF | Homo sapiens |
| RAF activation | Homo sapiens |
| Signal transduction by L1 | Homo sapiens |
| Signaling by BRAF and RAF1 fusions | Homo sapiens |
| Signaling by MAP2K mutants | Homo sapiens |
