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Signal transduction by L1

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-445144

PubChem

R-HSA-445144

Description

Besides adhesive roles in cell cell interaction, L1 functions as a signal transducing receptor providing neurons with cues from their environment for axonal growth and guidance. L1 associates with beta1 integrins on the cell surface to induce a signaling pathway involving sequential activation of pp60csrc, Vav2 -GEF, Rac1, PAK1, MEK and ERK1/2. L1 stimulates cell migration and neurite outgrowth through the MAP kinases ERK1/2. CHL1 also associates with integrins and activates a MAPK signaling pathway via pp60c-src, MEK and ERK1/2.
L1 also binds the Sema3A receptor neuropilin1 and acts as an obligate coreceptor to mediate Sema3A induced growth cone collapse and axon repulsion. This repulsion can be converted to attraction by homophilic binding of L1 on an apposing cell in trans with L1 complexed with Neuropilin1 (NP1) in the responding neuron.
L1 also interacts with FGF receptor and activates PLC gamma and DAG, resulting in the production of arachidonic acid and subsequent opening of voltage-gated channels.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 17 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O14786	Neuropilin-1	NRP NRP1 VEGF165R	view
P00533	Epidermal growth factor receptor	EGFR ERBB ERBB1 HER1	view
P05106	Integrin beta-3	GP3A ITGB3	view
P05556	Integrin beta-1	FNRB ITGB1 MDF2 MSK12	view
P06756	Integrin alpha-V	ITGAV MSK8 VNRA VTNR	view
P08514	Integrin alpha-IIb	GP2B ITGA2B ITGAB	view
P08648	Integrin alpha-5	FNRA ITGA5	view
P13591	Neural cell adhesion molecule 1	NCAM NCAM1	view
P19784	Casein kinase II subunit alpha'	CK2A2 CSNK2A2	view
P32004	Neural cell adhesion molecule L1	CAML1 L1CAM MIC5	view

Displaying 1 entry
GlyCosmos Lectin	UniProt ID	Lectin Name	Pathway Viewer
GL_002347	P13591	Neural cell adhesion molecule 1	view

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