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Integrin alpha-IIb
Summary
- UniProt ID
- P08514
- Gene Symbol
- GP2B ITGA2B ITGAB
- Gene ID
- 3674
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P08514
- PubChem
- P08514
- The Human Metabolome Database
- HMDBP02103
- RaftProt
- P08514
- Re-Glyco
- P08514
Annotation
- Keyword
- 3D-structure Alternative splicing Calcium Cell adhesion Cell membrane Cleavage on pair of basic residues Direct protein sequencing Disease variant Disulfide bond Glycoprotein Integrin Metal-binding Proteomics identification Pyrrolidone carboxylic acid Receptor Reference proteome Repeat Signal Transmembrane helix
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| angiogenesis | ||
| positive regulation of leukocyte migration | ||
| cell-matrix adhesion | ||
| integrin-mediated signaling pathway | ||
| integrin-mediated signaling pathway |
GO Hierarchy
| GO Term | Evidence Code | Reference |
|---|---|---|
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane | ||
| focal adhesion | ||
| external side of plasma membrane |
| GO Term | Evidence Code | Reference |
|---|---|---|
| signaling receptor activity | ||
| identical protein binding | ||
| metal ion binding |
|
|
| extracellular matrix binding | ||
| molecular adaptor activity |
GO Hierarchy
Sequence
MARALCPLQALWLLEWVLLLLGPCAAPPAWALNLDPVQLTFYAGPNGSQFGFSLDFHKDSHGRVAIVVGAPRTLGPSQEETGGVFLCPWRAEGGQCPSLLFDLRDETRNVGSQTLQTFKARQGLGASVVSWSDVIVACAPWQHWNVLEKTEEAEKTPVGSCFLAQPESGRRAEYSPCRGNTLSRIYVENDFSWDKRYCEAGFSSVVTQAGELVLGAPGGYYFLGLLAQAPVADIFSSYRPGILLWHVSSQSLSFDSSNPEYFDGYWGYSVAVGEFDGDLNTTEYVVGAPTWSWTLGAVEILDSYYQRLHRLRGEQMASYFGHSVAVTDVNGDGRHDLLVGAPLYMESRADRKLAEVGRVYLFLQPRGPHALGAPSLLLTGTQLYGRFGSAIAPLGDLDRDGYNDIAVAAPYGGPSGRGQVLVFLGQSEGLRSRPSQVLDSPFPTGSAFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRAQPVVKASVQLLVQDSLNPAVKSCVLPQTKTPVSCFNIQMCVGATGHNIPQKLSLNAELQLDRQKPRQGRRVLLLGSQQAGTTLNLDLGGKHSPICHTTMAFLRDEADFRDKLSPIVLSLNVSLPPTEAGMAPAVVLHGDTHVQEQTRIVLDCGEDDVCVPQLQLTASVTGSPLLVGADNVLELQMDAANEGEGAYEAELAVHLPQGAHYMRALSNVEGFERLICNQKKENETRVVLCELGNPMKKNAQIGIAMLVSVGNLEEAGESVSFQLQIRSKNSQNPNSKIVLLDVPVRAEAQVELRGNSFPASLVVAAEEGEREQNSLDSWGPKVEHTYELHNNGPGTVNGLHLSIHLPGQSQPSDLLYILDIQPQGGLQCFPQPPVNPLKVDWGLPIPSPSPIHPAHHKRDRRQIFLPEPEQPSRLQDPVLVSCDSAPCTVVQCDLQEMARGQRAMVTVLAFLWLPSLYQRPLDQFVLQSHAWFNVSSLPYAVPPLSLPRGEAQVWTQLLRALEERAIPIWWVLVGVLGGLLLLTILVLAMWKVGFFKRNRPPLEEDDEEGE
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 46 |
|
|
||
| 280 |
|
|
||
| 601 |
|
|
||
| 603 |
|
|
||
| 711 |
|
|
||
| 874 |
|
|
||
| 876 |
|
|||
| 878 |
|
|||
| 962 |
|
|
G53434XO
G58001LT
G43417UB
G29068FM
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| ECM proteoglycans | Homo sapiens |
| Fibrin formation | Homo sapiens |
| GRB2:SOS provides linkage to MAPK signaling for Integrins | Homo sapiens |
| Integrin cell surface interactions | Homo sapiens |
| Integrin signaling | Homo sapiens |
| MAP2K and MAPK activation | Homo sapiens |
| Paradoxical activation of RAF signaling by kinase inactive BRAF | Homo sapiens |
| Platelet degranulation | Homo sapiens |
| RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | Homo sapiens |
| Signal transduction by L1 | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060691 | platelet-type bleeding disorder 16 | |
| DOID:1588 | thrombocytopenia | |
| DOID:0060573 | von Willebrand's disease 1 | |
| DOID:2219 | Glanzmann's thrombasthenia |
