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MIRAGE
Integrin alpha-IIb

Summary
UniProt ID
P08514
Gene Symbol
  • GP2B
  • ITGA2B
  • ITGAB
Gene ID
3674
Organism
Homo sapiens (human)
GlyGen
P08514
PubChem
P08514
The Human Metabolome Database
HMDBP02103
RaftProt
P08514
Re-Glyco
P08514
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Calcium
  • Cell adhesion
  • Cleavage on pair of basic residues
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Glycoprotein
  • Integrin
  • Metal-binding
  • Pyrrolidone carboxylic acid
  • Receptor
  • Reference proteome
  • Repeat
  • Signal
  • Transmembrane helix
Gene Ontology (GO)
Displaying all 9 entries
GO Term
plasma membrane
external side of plasma membrane
cell surface
focal adhesion
integrin complex
extracellular exosome
blood microparticle
platelet alpha granule membrane
integrin alphaIIb-beta3 complex
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MARALCPLQALWLLEWVLLLLGPCAAPPAWALNLDPVQLTFYAGPNGSQFGFSLDFHKDSHGRVAIVVGAPRTLGPSQEETGGVFLCPWRAEGGQCPSLLFDLRDETRNVGSQTLQTFKARQGLGASVVSWSDVIVACAPWQHWNVLEKTEEAEKTPVGSCFLAQPESGRRAEYSPCRGNTLSRIYVENDFSWDKRYCEAGFSSVVTQAGELVLGAPGGYYFLGLLAQAPVADIFSSYRPGILLWHVSSQSLSFDSSNPEYFDGYWGYSVAVGEFDGDLNTTEYVVGAPTWSWTLGAVEILDSYYQRLHRLRGEQMASYFGHSVAVTDVNGDGRHDLLVGAPLYMESRADRKLAEVGRVYLFLQPRGPHALGAPSLLLTGTQLYGRFGSAIAPLGDLDRDGYNDIAVAAPYGGPSGRGQVLVFLGQSEGLRSRPSQVLDSPFPTGSAFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRAQPVVKASVQLLVQDSLNPAVKSCVLPQTKTPVSCFNIQMCVGATGHNIPQKLSLNAELQLDRQKPRQGRRVLLLGSQQAGTTLNLDLGGKHSPICHTTMAFLRDEADFRDKLSPIVLSLNVSLPPTEAGMAPAVVLHGDTHVQEQTRIVLDCGEDDVCVPQLQLTASVTGSPLLVGADNVLELQMDAANEGEGAYEAELAVHLPQGAHYMRALSNVEGFERLICNQKKENETRVVLCELGNPMKKNAQIGIAMLVSVGNLEEAGESVSFQLQIRSKNSQNPNSKIVLLDVPVRAEAQVELRGNSFPASLVVAAEEGEREQNSLDSWGPKVEHTYELHNNGPGTVNGLHLSIHLPGQSQPSDLLYILDIQPQGGLQCFPQPPVNPLKVDWGLPIPSPSPIHPAHHKRDRRQIFLPEPEQPSRLQDPVLVSCDSAPCTVVQCDLQEMARGQRAMVTVLAFLWLPSLYQRPLDQFVLQSHAWFNVSSLPYAVPPLSLPRGEAQVWTQLLRALEERAIPIWWVLVGVLGGLLLLTILVLAMWKVGFFKRNRPPLEEDDEEGE
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 9 entries
Position Description PubMed ID GlyTouCan ID Source
46 N-linked (GlcNAc...) asparagine
280 N-linked (GlcNAc...) asparagine
601 N-linked (GlcNAc...) asparagine
603
711 N-linked (GlcNAc...) asparagine
874
876
878 O-linked (GalNAc...) serine
962
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying entries 1 - 10 of 15 in total
Pathway Name Organism
ECM proteoglycans Homo sapiens
GRB2:SOS provides linkage to MAPK signaling for Integrins Homo sapiens
Integrin cell surface interactions Homo sapiens
Integrin signaling Homo sapiens
MAP2K and MAPK activation Homo sapiens
Paradoxical activation of RAF signaling by kinase inactive BRAF Homo sapiens
Platelet degranulation Homo sapiens
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Homo sapiens
Signal transduction by L1 Homo sapiens
Signaling by BRAF and RAF1 fusions Homo sapiens
Disease
Displaying all 4 entries
DO ID Disease Name Source
DOID:0060573 von Willebrand's disease 1
DOID:0060691 platelet-type bleeding disorder 16
DOID:1588 thrombocytopenia
DOID:2219 Glanzmann's thrombasthenia
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025