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Glycan Structure Repository
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Glycomics MS raw data Repository
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Glycomics MS Repository for glycan annotations from GlycoWorkbench
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Repository for lectin-assisted multimodality data
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Guidelines
MIRAGE
Glutamate receptor ionotropic, NMDA 2B
Summary
- UniProt ID
- Q13224
- Gene Symbol
-
- GRIN2B
- NMDAR2B
- Gene ID
- 2904
- Organism
- Homo sapiens (human)
External Links
- PubChem
- Q13224
- The Human Metabolome Database
- HMDBP01644
- Re-Glyco
- Q13224
Annotation
- Keyword
-
- 3D-structure
- Calcium
- Cell membrane
- Chromosomal rearrangement
- Cytoskeleton
- Disease variant
- Disulfide bond
- Endosome
- Epilepsy
- Glycoprotein
- Intellectual disability
- Ligand-gated ion channel
- Lysosome
- Magnesium
- Metal-binding
- Phosphoprotein
- Postsynaptic cell membrane
- Receptor
- Reference proteome
- Signal
- Transmembrane helix
- Zinc
- Gene Ontology (GO)
| GO Term |
|---|
| cytoplasm |
| dendrite |
| neuron projection |
| postsynaptic membrane |
| synaptic membrane |
| late endosome |
| endoplasmic reticulum membrane |
| cell surface |
| postsynaptic density |
| NMDA selective glutamate receptor complex |
Sequence
MKPRAECCSPKFWLVLAVLAVSGSRARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFHHLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEHLFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILRLLRTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLFSDYISEVERTFGNLQLKDSNVYQDHYHHHHRPHSIGSASSIDGLYDCDNPPFTTQSRSISKKPLDIGLPSSKHSQLSDLYGKFSFKSDRYSGHDDLIRSDVSDISTHTVTYGNIEGNAAKRRKQQYKDSLKKRPASAKSRREFDEIELAYRRRPPRSPDHKRYFRDKEGLRDFYLDQFRTKENSPHWEHVDLTDIYKERSDDFKRDSVSGGGPCTNRSHIKHGTGDKHGVVSGVPAPWEKNLTNVEWEDRSGGNFCRSCPSKLHNYSTTVTGQNSGRQACIRCEACKKAGNLYDISEDNSLQELDQPAAPVAVTSNASTTKYPQSPTNSKAQKKNRNKLRRQHSYDTFVDLQKEEAALAPRSVSLKDKGRFMDGSPYAHMFEMSAGESTFANNKSSVPTAGHHHHNNPGGGYMLSKSLYPDRVTQNPFIPTFGDDQCLLHGSKSYFFRQPTVAGASKARPDFRALVTNKPVVSALHGAVPARFQKDICIGNQSNPCVPNNKNPRAFNGSSNGHVYEKLSSIESDV
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 74 | N-linked (GlcNAc...) asparagine |
|
||
| 341 | N-linked (GlcNAc...) asparagine |
|
||
| 348 | N-linked (GlcNAc...) asparagine |
|
||
| 444 | N-linked (GlcNAc...) asparagine |
|
||
| 491 | N-linked (GlcNAc...) asparagine |
|
||
| 542 | N-linked (GlcNAc...) asparagine |
|
||
| 688 | N-linked (GlcNAc...) asparagine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activated NTRK2 signals through FYN | Homo sapiens |
| Assembly and cell surface presentation of NMDA receptors | Homo sapiens |
| EPHB-mediated forward signaling | Homo sapiens |
| Long-term potentiation | Homo sapiens |
| MECP2 regulates neuronal receptors and channels | Homo sapiens |
| Negative regulation of NMDA receptor-mediated neuronal transmission | Homo sapiens |
| Neurexins and neuroligins | Homo sapiens |
| RAF/MAP kinase cascade | Homo sapiens |
| Ras activation upon Ca2+ influx through NMDA receptor | Homo sapiens |
| Synaptic adhesion-like molecules | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050742 | nicotine dependence | |
| DOID:0070036 | autosomal dominant intellectual developmental disorder 6 | |
| DOID:0080444 | developmental and epileptic encephalopathy 27 | |
| DOID:10652 | Alzheimer's disease | |
| DOID:12858 | Huntington's disease | |
| DOID:1574 | alcohol use disorder | |
| DOID:3083 | chronic obstructive pulmonary disease | |
| DOID:3312 | bipolar disorder | |
| DOID:5419 | schizophrenia |
