GlyCosmos Portal

Submissions

Negative regulation of NMDA receptor-mediated neuronal transmission

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9617324

PubChem

R-HSA-9617324

Description

The duration of NMDA receptor-mediated neuronal transmission can be limited by binding of the activated calmodulin to the activated NMDA receptor. In addition to shortening the NMDA channel pore open state, calmodulin interferes with ACTN2-mediated anchoring of NMDA receptors to the postsynaptic density (Ehlers et al. 1996, Wyszynski et al. 1997). Protein phosphatases PPM1E and PPM1F dephosphorylate activated calcium/calmodulin-dependent kinases (CaMKs), thus halting CaMK-mediated signaling (Ishida, Okuno et al. 1998, Ishida et al. 1998, Kitani et al. 2003).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 15 in total

1

2

Next ›

Last »
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O15399	Glutamate receptor ionotropic, NMDA 2D	GRIN2D GluN2D NMDAR2D	view
P07196	Neurofilament light polypeptide	NEFL NF68 NFL	view
P35609	Alpha-actinin-2	ACTN2	view
P49593	Protein phosphatase 1F	KIAA0015 POPX2 PPM1F	view
Q05586	Glutamate receptor ionotropic, NMDA 1	GRIN1 NMDAR1	view
Q12879	Glutamate receptor ionotropic, NMDA 2A	GRIN2A NMDAR2A	view
Q12959	Disks large homolog 1	DLG1	view
Q13224	Glutamate receptor ionotropic, NMDA 2B	GRIN2B NMDAR2B	view
Q13554	Calcium/calmodulin-dependent protein kinase type II subunit beta	CAM2 CAMK2 CAMK2B CAMKB	view
Q13555	Calcium/calmodulin-dependent protein kinase type II subunit gamma	CAMK CAMK-II CAMK2G CAMKG	view

If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".

About Release Notes Help Feedback

Click here to visit the beta site.