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NAD(P) transhydrogenase, mitochondrial

Summary

UniProt ID: Q5BJZ3
Gene Symbol: Nnt
Gene ID: 310378
Organism: Rattus norvegicus (Norway rat)

External Links

GlyGen: Q5BJZ3
The O-GlcNAc Database: Q5BJZ3
O-GlcNAcAtlas: Q5BJZ3
Re-Glyco: Q5BJZ3

Annotation

Keyword: Acetylation Mitochondrion inner membrane NAD NADP Proteomics identification Reference proteome Transit peptide Translocase Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
NADPH regeneration	IMP	PMID
NADPH regeneration	IBA	GO_REF
positive regulation of mitochondrial membrane potential	IMP	PMID
intracellular oxygen homeostasis	IMP	PMID
response to vitamin	IEP	PMID

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

generation of precursor metabolites and energy [inference]

NADPH regeneration

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP+ metabolic process [inference]

NADPH regeneration

nicotinamide nucleotide metabolic process [inference]

NADP+ metabolic process [inference]

NADPH regeneration

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP+ metabolic process [inference]

NADPH regeneration

nicotinamide nucleotide metabolic process [inference]

NADP+ metabolic process [inference]

NADPH regeneration

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP+ metabolic process [inference]

NADPH regeneration

nicotinamide nucleotide metabolic process [inference]

NADP+ metabolic process [inference]

NADPH regeneration

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP+ metabolic process [inference]

NADPH regeneration

nicotinamide nucleotide metabolic process [inference]

NADP+ metabolic process [inference]

NADPH regeneration

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP+ metabolic process [inference]

NADPH regeneration

pyridine-containing compound metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP+ metabolic process [inference]

NADPH regeneration

reactive oxygen species metabolic process

cellular detoxification [inference]

cellular oxidant detoxification

homeostatic process [inference]

cellular homeostasis [inference]

cell redox homeostasis

intracellular chemical homeostasis [inference]

intracellular oxygen homeostasis

chemical homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular oxygen homeostasis

response to stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin

response to chemical [inference]

response to nutrient [inference]

response to vitamin

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of hydrogen peroxide catabolic process

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of hydrogen peroxide catabolic process

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of hydrogen peroxide catabolic process

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of hydrogen peroxide catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of hydrogen peroxide catabolic process

regulation of hydrogen peroxide catabolic process [inference]

positive regulation of hydrogen peroxide catabolic process

regulation of reactive oxygen species metabolic process [inference]

regulation of hydrogen peroxide metabolic process [inference]

regulation of hydrogen peroxide catabolic process [inference]

positive regulation of hydrogen peroxide catabolic process

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of hydrogen peroxide catabolic process

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of hydrogen peroxide catabolic process

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of hydrogen peroxide catabolic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of biological quality [inference]

regulation of membrane potential [inference]

positive regulation of membrane potential [inference]

positive regulation of mitochondrial membrane potential

regulation of mitochondrial membrane potential [inference]

positive regulation of mitochondrial membrane potential

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

Displaying **all 2** entries
GO Term	Evidence Code	Reference
mitochondrion	ISO	GO_REF
mitochondrial inner membrane	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 4** entries
GO Term	Evidence Code	Reference
proton-translocating NAD(P)+ transhydrogenase activity	IEA	GO_REF
oxidoreductase activity	IEA	GO_REF
NADP binding	ISO	GO_REF
NADP binding	IBA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

proton-translocating NAD(P)+ transhydrogenase activity

active monoatomic ion transmembrane transporter activity [inference]

proton-translocating NAD(P)+ transhydrogenase activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

oxidoreduction-driven active transmembrane transporter activity [inference]

proton-translocating NAD(P)+ transhydrogenase activity

active monoatomic ion transmembrane transporter activity [inference]

proton-translocating NAD(P)+ transhydrogenase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MAHLLKTVVTGCLCPSVSNLGSCKVLPGKKDFLRTFRTHQALWCKSPAKPGIPYKQLTVGVPKEIFQNEKRVALSPAGVQALVKQGFNVVVESGAGEASKFPDDLYRAAGAQIQGTKEVLASDLVVKVRAPMVNPTLGAHEADFLKPSGTLISFIYPAQNPDLLNKLSERKTTVLAMDQVPRVTIAQGYDALSSMANISGYKAVVLAANHFGRFFTGQITAAGKVPPAKILIVGGGVAGLASAGAAKSMGAVVRGFDTRAAALEQFKSLGAEPLEVDLKESGEGQGGYAKEMSKEFIEAEMKLFAQQCKEVDILISTALIPGKKAPVLFSKEMIESMKEGSVVVDLAAEAGGNFETTKPGELYVHKGITHIGYTDLPSRMATQASTLYSNNITKLLKAISPDKDNFHFEVKDDFDFGTMSHVIRGTVVMKDGNVIFPAPTPKNIPKEAPAKQKTVAELEAEKAGTVSMYTKTLRTASVYSAGLTGMLGLGIVAPNLAFSQMVTTFGLAGIIGYHTVWGVTPALHSPLMSVTNAISGLTAVGGLALMGGHFYPSTTSQSLAALATFISSVNIAGGFLVTQRMLDMFKRPTDPPEYNYLYLLPGGTFVGGYLAALYGGYNIEEIMYLGSGLCCVGALGGLSTQGTARLGNALGMIGVAGGLAATLGGLKPDPQLLAQMSGAMAMGGTIGLAIAKRIQISDLPQLVAAFHSLVGLAAVLTCMAEYIVEYPHFAMDATSNFTKIVAYIGTYIGGVTFSGSLVAYGKLQGILKSAPLLLPGRHALNAGLLAASVGGIIPFMADPSFTTGIMCLGSVSALSTLMGVTLTAAIGGADMPVVITVLNSYSGWALCAEGFLLNNNLLTIVGALIGSSGAILSYIMCVAMNRSLANVILGGYGTTSTAGGKPMEISGTHTEINLDNAVEMIREANSIVITPGYGLCAAKAQYPIADLVKMLTEQGKKVRFGIHPVAGRMPGQLNVLLAEAGVPYDIVLEMDEINSDFPDTDLVLVIGANDTVNSAAQEDPNSIIAGMPVLEVWKSKQVIVMKRSLGVGYAAVDNPIFYKPNTAMLLGDAKKTCDALQAKVRESYQK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	PubMed ID	GlyTouCan ID	Source
93	26446791 27213235 34502162	G49108TO	GlyGen The O-GlcNAc Database
242	26446791 27213235 34502162	G49108TO	GlyGen The O-GlcNAc Database
281	26446791 27213235 34502162	G49108TO	GlyGen The O-GlcNAc Database
330	26446791 27213235 34502162	G49108TO	GlyGen The O-GlcNAc Database
378	26446791 27213235 34502162	G49108TO	GlyGen The O-GlcNAc Database
520			GlyGen