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RAC-beta serine/threonine-protein kinase
Summary
- UniProt ID
- Q60823
- Gene Symbol
-
- Akt2
- Gene ID
- [11652]
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
- ATP-binding Acetylation Apoptosis Cell membrane Cytoplasm Developmental protein Disulfide bond Endosome Glucose metabolism Glycogen biosynthesis Glycogen metabolism Glycoprotein Manganese Metal-binding Nucleus Phosphoprotein Reference proteome Serine/threonine-protein kinase Sugar transport Translation regulation Ubl conjugation
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| glycogen biosynthetic process |
|
|
| glucose metabolic process | ||
| insulin receptor signaling pathway | ||
| insulin receptor signaling pathway | ||
| insulin receptor signaling pathway |
GO Hierarchy
biological process
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of signaling [inference]
regulation of localization [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of transmembrane transport [inference]
positive regulation of cellular process [inference]
| GO Term | Evidence Code | Reference |
|---|---|---|
| protein kinase activity | ||
| protein kinase activity | ||
| protein serine/threonine kinase activity | ||
| protein serine/threonine kinase activity | ||
| protein serine/threonine kinase activity |
Sequence
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRGPGEDAMDYKCGSPSDSSTSEMMEVAVNKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEDRARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLGPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLDPLELDQRTHFPQFSYSASIRE
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 128 |
|
|
||
| 131 |
|
|
||
| 306 |
|
|
||
| 313 |
|
|
||
| 474 |
|
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| AKT phosphorylates targets in the cytosol | Mus musculus |
| AKT phosphorylates targets in the nucleus | Mus musculus |
| AKT-mediated inactivation of FOXO1A | Mus musculus |
| Activation of PKB | Mus musculus |
| CD28 dependent PI3K/Akt signaling | Mus musculus |
| Co-inhibition by CTLA4 | Mus musculus |
| Cyclin A:Cdk2-associated events at S phase entry | Mus musculus |
| Cyclin E associated events during G1/S transition | Mus musculus |
| Deactivation of the beta-catenin transactivating complex | Mus musculus |
| Downregulation of ERBB2:ERBB3 signaling | Mus musculus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:9352 | type 2 diabetes mellitus | |
| DOID:11612 | polycystic ovary syndrome |
