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Glutathione hydrolase 1 proenzyme

Summary

UniProt ID: Q60928
Gene Symbol: Ggt Ggt1 Ggtp
Gene ID: 14598
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB

GPDB0005429

GlyConnect

Gamma-glutamyltranspeptidase 1

GlyGen

Q60928

PubChem

Q60928

Re-Glyco

Q60928

Annotation

Keyword: Acyltransferase Cell membrane Disulfide bond Glutathione biosynthesis Glycoprotein Protease Reference proteome Signal-anchor Transmembrane helix Zymogen

Gene Ontology (GO)

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	Reference
regulation of immune system process	IMP	PMID
regulation of immune system process	IBA	GO_REF
glutamate metabolic process	ISS	GO_REF
glutathione metabolic process	TAS	PMID
glutathione metabolic process	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

peptide metabolic process [inference]

peptide modification

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

modified amino acid metabolic process [inference]

glutathione metabolic process

modified amino acid catabolic process [inference]

glutathione catabolic process

modified amino acid biosynthetic process [inference]

glutathione biosynthetic process

sulfur compound metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

glutathione metabolic process

sulfur compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

glutathione biosynthetic process

sulfur compound catabolic process [inference]

glutathione catabolic process

catabolic process [inference]

modified amino acid catabolic process [inference]

glutathione catabolic process

sulfur compound catabolic process [inference]

glutathione catabolic process

biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

L-amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

modified amino acid biosynthetic process [inference]

glutathione biosynthetic process

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

sulfur compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

glutathione biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

proteinogenic amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

L-amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

zymogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

L-amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

proteinogenic amino acid metabolic process [inference]

proteinogenic amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

alpha-amino acid metabolic process [inference]

glutamate metabolic process

L-amino acid metabolic process [inference]

L-amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

L-amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

zymogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

proteinogenic amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

L-amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

dicarboxylic acid metabolic process [inference]

glutamate metabolic process

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

proteinogenic amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

L-amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

proteinogenic amino acid metabolic process [inference]

proteinogenic amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

alpha-amino acid metabolic process [inference]

glutamate metabolic process

L-amino acid metabolic process [inference]

L-amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

L-amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

proteinogenic amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

L-amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

stem cell differentiation [inference]

hepatoblast differentiation

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

anatomical structure development [inference]

regeneration [inference]

animal organ regeneration [inference]

liver regeneration

animal organ development [inference]

animal organ regeneration [inference]

liver regeneration

gland development [inference]

liver development [inference]

liver regeneration

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

stem cell differentiation [inference]

hepatoblast differentiation

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

cellular response to oxidative stress

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to chemical [inference]

response to lipid [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

response to peptide [inference]

response to cytokine [inference]

response to tumor necrosis factor

response to oxygen-containing compound [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of inflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of inflammatory response

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
obsolete extracellular space
endoplasmic reticulum	ISO	GO_REF
plasma membrane	ISS	GO_REF
plasma membrane	ISO	GO_REF
plasma membrane	TAS	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	Reference
peptidyltransferase activity	ISO	GO_REF
leukotriene-C(4) hydrolase activity	ISO	GO_REF
leukotriene-C(4) hydrolase activity	IEA	GO_REF GO_REF
aminoacyltransferase activity	ISO	GO_REF
aminoacyltransferase activity	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity

peptidyltransferase activity

hydrolase activity [inference]

peptidase activity [inference]

omega peptidase activity [inference]

threonine-type peptidase activity [inference]

glutathione gamma-glutamate hydrolase

catalytic activity, acting on a protein [inference]

peptidyltransferase activity

peptidase activity [inference]

omega peptidase activity [inference]

threonine-type peptidase activity [inference]

glutathione gamma-glutamate hydrolase

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

catalytic activity, acting on a tRNA [inference]

peptidyltransferase activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MKNRFLVLGLVAVVLVFVIIGLCIWLPYTSGKPDHVYSRAAVATDAKRCSEIGRDILQEGGSVVDAAIASLLCMGLMNAHSMGIGGGLFFTIYNSTTGKVEVINAREVAPRLANTTMFNNSKDSEEGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARHGFPVGKGLAIALDKKRDVIEKTPALCEVFCRQGKVLQEGETVTMPKLADTLQILAQEGAKAFYNGSLTAQIVKDIQEAGGIMTVEDLNNYRAELIEHPMSIGLGDATLYVPSAPLSGPVLILILNILKGYNFSPKSVATPEQKALTYHRIVEAFRFAYAKRTMLGDPKFVDVSQVIRNMSSEFYATQLRARITDETTHPAAYYEPEFYLQDDGGTAHLSAVSEDGSAVAATSTINLYFGSKVLSRVSGILFNDEMDDFSSPNFINQFRVAPSPANFIKPGKQPLSSMCPSIILDKDGQVRMVVGASGGTQITTSVALAIINSLWFGYDVKRAVEEPRLHNQLLPNTTTVEKDIDQVVTAGLKIRHHHTEVTPTFIAVVQAVVRASGGWAAASDSRKGGEPAGY

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
94	N-linked (GlcNAc...) asparagine			GlycoProtDB UniProt GlyGen
114	N-linked (GlcNAc...) asparagine	19349973	G44753VC	GlycoProtDB UniProt GlyGen
119	N-linked (GlcNAc...) asparagine		G12341GU	GlycoProtDB UniProt GlyGen
229	N-linked (GlcNAc...) asparagine	19349973	G27947YN	GlycoProtDB UniProt GlyGen
343	N-linked (GlcNAc...) asparagine		G20528HD G54678CA G44231RW G57471MV G15908WF G44437FL G02281EI G13749ZZ G27336AY G22267GY	GlycoProtDB UniProt GlyGen
510	N-linked (GlcNAc...) asparagine	19349973 30899004	G72000PU G06110VR	GlycoProtDB UniProt GlyGen GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
APAP ADME	Mus musculus
Aflatoxin activation and detoxification	Mus musculus
Glutathione synthesis and recycling	Mus musculus
Synthesis of Leukotrienes (LT) and Eoxins (EX)	Mus musculus