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Mothers against decapentaplegic homolog 2

Summary

UniProt ID

Q62432

Gene Symbol

Madh2
Madr2
Smad2

Gene ID

17126

Organism

Mus musculus (house mouse)

External Links

GlyGen: Q62432
PubChem: Q62432
The Human Metabolome Database: HMDBP14505
Re-Glyco: Q62432

Annotation

Keyword

Acetylation
Alternative splicing
Cytoplasm
DNA-binding
Metal-binding
Nucleus
Phosphoprotein
Reference proteome
Transcription regulation
Ubl conjugation
Zinc

Gene Ontology (GO)

Displaying **all 8** entries
GO Term
nucleoplasm
transcription regulator complex
activin responsive factor complex
heteromeric SMAD protein complex
homomeric SMAD protein complex
chromatin
nucleus
cytoplasm

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 50 in total

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GO Term
gastrulation
pattern specification process
endoderm development
cell population proliferation
negative regulation of cell population proliferation
post-embryonic development
positive regulation of gene expression
negative regulation of gene expression
signal transduction involved in regulation of gene expression
insulin secretion

Displaying entries **1 - 10** of 18 in total

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GO Term
chromatin binding
metal ion binding
RNA polymerase II cis-regulatory region sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
type I transforming growth factor beta receptor binding
identical protein binding
SMAD binding
RNA polymerase II-specific DNA-binding transcription factor binding
I-SMAD binding
DNA-binding transcription factor binding

Annotation information from UniProt.

Sequence

MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKTGRLDELEKAITTQNCNTKCVTIPSTCSEIWGLSTANTVDQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQSMDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
322			G02815KT	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 8** entries
Pathway Name	Organism
Downregulation of SMAD2/3:SMAD4 transcriptional activity	Mus musculus
Downregulation of TGF-beta receptor signaling	Mus musculus
FOXO-mediated transcription of cell cycle genes	Mus musculus
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	Mus musculus
Signaling by Activin	Mus musculus
Signaling by NODAL	Mus musculus
TGF-beta receptor signaling activates SMADs	Mus musculus
Ub-specific processing proteases	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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External Links

Annotation

International Collaboration

Acknowledgements