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Downregulation of SMAD2/3:SMAD4 transcriptional activity

Summary

Organism

Mus musculus (house mouse)

Reactome

R-MMU-2173795

PubChem

R-MMU-2173795

Description

This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 13 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O09106	Histone deacetylase 1	Hdac1	view
P0CG49	Polyubiquitin-B [Cleaved into: Ubiquitin]	Ubb	view
P11103	Poly [ADP-ribose] polymerase 1	Adprp Adprt Adprt1 Parp1	view
P70398	Ubiquitin carboxyl-terminal hydrolase 9X	Fafl Fam Usp9x	view
P97471	SMAD family member 4	Dpc4 Madh4 Smad4	view
Q60665	Ski-like protein	Skil Skir Sno	view
Q60698	Ski oncogene	Ski	view
Q60974	Nuclear receptor corepressor 1	Ncor1 Rxrip13	view
Q62432	SMAD family member 2	Madh2 Madr2 Smad2	view
Q8CFI0	E3 ubiquitin-protein ligase NEDD4-like	Kiaa0439 Nedd4b Nedd4l	view

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